https://scholars.lib.ntu.edu.tw/handle/123456789/523541
標題: | The miRNAs and epithelial-mesenchymal transition in cancers | 作者: | Lin C.-W. Kao S.-H. PAN-CHYR YANG |
關鍵字: | Cancers; EMT; Epithelial-mesenchymal transition; miRNAs | 公開日期: | 2014 | 出版社: | Bentham Science Publishers B.V. | 卷: | 20 | 期: | 33 | 起(迄)頁: | 5309-5318 | 來源出版物: | Current Pharmaceutical Design | 摘要: | The epithelial-mesenchymal transition (EMT) is a process by which epithelial tumor cells acquire migratory and invasive abilities that enable them to spread to other organs. During this process, the tight junction molecule, E-cadherin, is often downregulated through transcription repression by the EMT-inducing transcription factors (EMT-TFs). MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which bind to the complementary sequences within mRNA molecules. They post-transcriptionally govern gene silencing, thus affecting a broad range of physiological conditions, including EMT. In this review, we will discuss some well-known as well as brand-new EMT-related miRNAs and the signaling pathways in the tumor milieu that regulate their expressions and control cancer invasion and metastasis. Finally, we will discuss the application of miRNAs as therapeutic targets for treatment of cancer. ? 2014 Bentham Science Publishers. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926320208&doi=10.2174%2f1381612820666140128204508&partnerID=40&md5=7b3cbcaea40eb0ea47e5b481a417a903 https://scholars.lib.ntu.edu.tw/handle/123456789/523541 |
ISSN: | 1381-6128 | DOI: | 10.2174/1381612820666140128204508 | SDG/關鍵字: | microRNA; microRNA 200; microRNA 203; microRNA 580; microRNA let 7; small untranslated RNA; transcription factor; unclassified drug; uvomorulin; microRNA; Article; cancer therapy; carcinogenesis; drug design; drug targeting; epigenetics; epithelial mesenchymal transition; gene expression; gene repression; gene silencing; Hippo pathway; human; hypoxia; inflammation; malignant neoplastic disease; metastasis; molecular biology; nonhuman; priority journal; regulatory mechanism; signal transduction; tight junction; transcription regulation; tumor invasion; animal; genetics; metabolism; Neoplasms; Animals; Epithelial-Mesenchymal Transition; Humans; MicroRNAs; Neoplasms |
顯示於: | 醫學系 |
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