https://scholars.lib.ntu.edu.tw/handle/123456789/523542
標題: | Intrapleural minocycline pleurodesis for the treatment of primary spontaneous pneumothorax | 作者: | JIN-SHING CHEN Chan W.-K. PAN-CHYR YANG |
公開日期: | 2014 | 出版社: | Lippincott Williams and Wilkins | 卷: | 20 | 期: | 4 | 起(迄)頁: | 371-376 | 來源出版物: | Current Opinion in Pulmonary Medicine | 摘要: | Purpose of Review: The role of chemical pleurodesis in the treatment of primary spontaneous pneumothorax remains unclear. According to current practice guidelines, chemical pleurodesis is reserved for patients who are unable or unwilling to have surgery. Some recent studies showed that intrapleural minocycline pleurodesis could decrease the rate of pneumothorax recurrence, when used either as the initial treatment for simple pneumothorax after successful aspiration and drainage or as an adjuvant treatment for complicated or recurrent pneumothorax following thoracoscopic surgery. The purpose of this review is to discuss the current available evidence on intrapleural minocycline pleurodesis for the treatment of primary spontaneous pneumothorax. Recent Findings: In a recently published prospective, randomized controlled trial, additional minocycline pleurodesis following simple aspiration and drainage was a well tolerated and more effective initial treatment for a first episode of primary spontaneous pneumothorax than simple aspiration and drainage alone. Other prospective, randomized controlled trials showed that additional minocycline pleurodesis after thoracoscopic treatment was a well tolerated and convenient procedure which can reduce the rate of ipsilateral recurrence of primary spontaneous pneumothorax. Summary: Intrapleural minocycline pleurodesis can be considered an adjunct to standard treatment of primary spontaneous pneumothorax, after either simple aspiration and drainage or after thoracoscopic surgery. Copyright ? 2014 Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901848553&doi=10.1097%2fMCP.0000000000000067&partnerID=40&md5=69ec2ed82cb71e42e246830ebaeafe0f https://scholars.lib.ntu.edu.tw/handle/123456789/523542 |
ISSN: | 1070-5287 | DOI: | 10.1097/MCP.0000000000000067 | SDG/關鍵字: | doxycycline; minocycline; tetracycline; antiinfective agent; minocycline; narcotic agent; human; lung resection; nonhuman; pleurectomy; pleurodesis; pneumothorax; review; spontaneous pneumothorax; thorax drainage; Chest Pain; Drainage; pneumothorax; procedures; randomized controlled trial (topic); recurrent disease; thoracoscopy; treatment outcome; Anti-Bacterial Agents; Chest Pain; Drainage; Humans; Minocycline; Narcotics; Pleurodesis; Pneumothorax; Randomized Controlled Trials as Topic; Recurrence; Thoracoscopy; Treatment Outcome |
顯示於: | 醫學系 |
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