https://scholars.lib.ntu.edu.tw/handle/123456789/523547
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kuo T. | en_US |
dc.contributor.author | Lai W. | en_US |
dc.contributor.author | Li C. | en_US |
dc.contributor.author | Wun Y. | en_US |
dc.contributor.author | Chang H. | en_US |
dc.contributor.author | Chen J. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.contributor.author | Chen C. | en_US |
dc.creator | Kuo T.;Lai W.;Li C.;Wun Y.;Chang H.;Chen J.;PAN-CHYR YANG;Chen C. | - |
dc.date.accessioned | 2020-12-02T02:33:44Z | - |
dc.date.available | 2020-12-02T02:33:44Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1998-0124 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84900561094&doi=10.1007%2fs12274-014-0420-4&partnerID=40&md5=84d6adb034e4fde09f5ab2baefa344a1 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/523547 | - |
dc.description.abstract | Europium-doped gadolinium oxide (Gd2O3:Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolintargeted AS1411 aptamer to form functionalized target-specific Gd2O3:Eu nanoparticles (A-GdO:Eu nanoparticles). The A-GdO:Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO:Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T 1 contrast and strong computed tomography (CT) signal, the A-GdO:Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance (MR) molecular imaging. Animal experiments also show that the A-GdO:Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO:Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO:Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future. [Figure not available: see fulltext.] ? 2014 Tsinghua University Press and Springer-Verlag Berlin Heidelberg. | - |
dc.publisher | Tsinghua University Press | - |
dc.relation.ispartof | Nano Research | - |
dc.subject | aptamer; contrast agent; molecular imaging; nanoparticles synthesis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s12274-014-0420-4 | - |
dc.identifier.scopus | 2-s2.0-84900561094 | - |
dc.relation.pages | 658-669 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 5 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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