Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients
Journal
Emerging Infectious Diseases
Journal Volume
10
Journal Issue
5
Pages
818-824
Date Issued
2004
Author(s)
Abstract
Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.
SDGs
Other Subjects
aminotransferase; C reactive protein; creatine kinase; immunoglobulin; lactate dehydrogenase; methylprednisolone; ribavirin; steroid; adult; aged; article; clinical feature; coughing; death; diarrhea; disease exacerbation; dyspnea; fatality; female; fever; human; laboratory test; lymphocytopenia; major clinical study; male; myalgia; pneumonia; prospective study; severe acute respiratory syndrome; symptomatology; thrombocytopenia; treatment outcome
Publisher
Centers for Disease Control and Prevention (CDC)
Type
journal article
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