https://scholars.lib.ntu.edu.tw/handle/123456789/524024
標題: | Comparison of inflammatory cytokine concentration and physiologic parameters in septic shock | 作者: | Liaw Y.-S. CHONG-JEN YU HUEY-DONG WU PAN-CHYR YANG |
公開日期: | 1997 | 卷: | 96 | 期: | 9 | 起(迄)頁: | 685-690 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Cytokine-related systemic intravascular inflammation may represent a common pathogenic link between initial insult and multiple organ failure in septic shock patients. We conducted a prospective study with controls in the National Taiwan University Hospital intensive care unit to compare plasma levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and circulating intercellular adhesion molecule 1 (cICAM-1) with clinical physiologic parameters in the outcome of patients with septic shock. Healthy volunteers (n = 37) and patients with septic shock admitted to the unit from January to December 1994 (n = 31) were enrolled. Clinical data, APACHE (Acute Physiology and Chronic Health Evaluation) III scores, multiple organ failure scores, the presence of acute respiratory distress syndrome, and outcome were evaluated. The plasma levels of TNF-α, IL-6, and cICAM-1 were measured using enzyme-linked immunosorbent assay. Subgroups of survivors and nonsurvivors were compared for plasma levels of these factors on days 1, 2, 3, 7, and 14 after diagnosis of septic shock. Of the patients with septic shock, 20 survived and 11 died. The initial plasma levels of IL-6 were significantly higher in nonsurvivors (p < 0.05). There was a significant inverse correlation between plasma IL-6 level and survival in the first week (r = 0.4297-0.7242, p < 0.05). APACHE III score (r = 0.4335, p = 0.015), acute respiratory distress syndrome (r = 0.5913, p < 0.001), and multiple organ failure store (r = 0.736, p < 0.001) were more strongly (negatively) correlated with survival than the concentrations of TNF-α and cICAM-1 by Spearman's rank sum test. Our results showed that in patients with septic shock, of the inflammatory cytokines, only IL-6 showed significantly higher plasma levels in the nonsurvivor group. Inflammatory cytokine levels were not more strongly correlated with the outcome of patients with septic shock than physiologic parameters. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030885872&partnerID=40&md5=47b5320d7f76bcb807b84fac9b98c94c https://scholars.lib.ntu.edu.tw/handle/123456789/524024 |
ISSN: | 0929-6646 | SDG/關鍵字: | cytokine; intercellular adhesion molecule 1; interleukin 6; lipopolysaccharide; tumor necrosis factor alpha; adult; aged; article; clinical article; controlled study; enzyme linked immunosorbent assay; female; human; male; multiple organ failure; respiratory distress; septic shock; Adult; Aged; Aged, 80 and over; Cytokines; Female; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Middle Aged; Prospective Studies; Shock, Septic; Tumor Necrosis Factor-alpha |
顯示於: | 醫學系 |
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