|Title:||Riociguat improves pulmonary hemodynamics in patients with inoperable chronic thromboembolic pulmonary hypertension||Authors:||CHENG-HSUAN TSAI
|Issue Date:||2020||Publisher:||Republic of China Society of Cardiology||Journal Volume:||36||Journal Issue:||1||Start page/Pages:||64-71||Source:||Acta Cardiologica Sinica||Abstract:||
Background: Few studies have investigated the effects of riociguat on pulmonary hemodynamics in Asian patients with chronic thromboembolic pulmonary hypertension (CTEPH). In this study, we evaluated the effects of riociguat on pulmonary hemodynamics in inoperable CTEPH patients. Methods: We retrospectively collected the clinical data of 11 inoperable CTEPH patients. Pulmonary hemodynamic parameters of right heart catheterization, echocardiography, 6-minute walk distance and World Health Organization (WHO) functional class were assessed at baseline and after riociguat treatment. Results: The median duration of riociguat treatment was 12 months, and all 11 patients tolerated riociguat 7.5 mg/day well after titration. With regards to pulmonary hemodynamic data, both mean pulmonary artery pressure and pulmonary vascular resistance significantly decreased from 41 ? 8 mmHg to 38 ? 9 mmHg (p = 0.045) and 787 ? 417 dyn·s·cm-5 to 478 ? 267 dyn·s·cm-5 (p = 0.007), respectively. With regards to clinical symptoms, WHO functional class significantly improved in nine of the 11 patients, and there was no change in the other two patients (p = 0.004). In addition, the median level of N-terminal pro-brain natriuretic peptide also significantly decreased from 281 (117-5943) pg/ml to 226 (48-1276) pg/ml (p = 0.021). Conclusions: Riociguat treatment improved both clinical symptoms and pulmonary hemodynamics in the inoperative CTEPH patients in this study. ? 2020, Republic of China Society of Cardiology. All rights reserved.
|ISSN:||1011-6842||DOI:||10.6515/ACS.202001_36(1).20190612A||SDG/Keyword:||alanine aminotransferase; amino terminal pro brain natriuretic peptide; aspartate aminotransferase; bilirubin; cholesterol; high density lipoprotein; low density lipoprotein; riociguat; triacylglycerol; anticoagulant therapy; antiphospholipid syndrome; Article; autoimmune hemolytic anemia; biochemical analysis; chronic thromboembolic pulmonary hypertension; clinical article; coronary artery disease; coronary vascular resistance; diabetes mellitus; echocardiography; end stage renal disease; endarterectomy; female; follow up; heart catheterization; heart left ventricle ejection fraction; heart left ventricle enddiastolic diameter; heart output; heart right atrium pressure; hospitalization; human; hypertension; lung angiography; lung artery pressure; lung embolism; lung hemodynamics; lung vascular resistance; lung wedge pressure; male; maximum tolerated dose; mortality; pulmonary artery occlusion pressure; retrospective study; six minute walk test; tricuspid valve regurgitation; venous thromboembolism
|Appears in Collections:||醫學系|
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