Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Demonstrating the pharmacogenetic effects of angiotensin-converting enzyme inhibitors on long-term prognosis of diastolic heart failure
 
  • Details

Demonstrating the pharmacogenetic effects of angiotensin-converting enzyme inhibitors on long-term prognosis of diastolic heart failure

Journal
Pharmacogenomics Journal
Journal Volume
10
Journal Issue
1
Pages
46-53
Date Issued
2010
Author(s)
CHO-KAI WU  
Luo J.-L.
CHIA-TI TSAI  
Huang Y.-T.
Cheng C.-L.
JEN-KUANG LEE  
LIAN-YU LIN  
JOU-WEI LIN  
HWANG, JUEY-JEN  
FU-TIEN CHIANG  
DOI
10.1038/tpj.2009.39
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-75549089270&doi=10.1038%2ftpj.2009.39&partnerID=40&md5=4656aeefacf121b6326aee0d73206aa7
https://scholars.lib.ntu.edu.tw/handle/123456789/524288
Abstract
The objective of this study was to evaluate the effects of angiotensin-converting enzyme (ACE) inhibitors and pharmacogenetic interaction on the survival of the patients with diastolic heart failure (DHF). A total of 285 subjects with DHF confirmed by echocardiography were recruited in the period between 1995 and 2003. Baseline characteristics (age, sex, prior history, medication, and echocardiographic findings) and genetic polymorphisms (ACE gene insertion/deletion (I/D) polymorphism; T174M, M235T, G-6A, A-20C, G-152A, and G-217A polymorphisms of the angiotensinogen (AGT) gene; and A1166C polymorphisms of the angiotensin II type I receptor (AT1R)) were collected and matched (by propensity score) in those who received and those who did not receive ACE inhibitors. The patients were followed up to 10 years. Kaplan-Meier curves and Cox regression models were used to demonstrate the survival trend. The 85 patients who received ACE inhibitors and the other 85 patients who did not were found to have comparable baseline characteristics and polymorphism distribution. Prescription of ACE inhibitors was associated with a significant decrease in overall mortality (hazard ratio (HR), 0.45; 95% confidence interval (CI), 0.24-0.83; P0.01), and a lower rate of cardiovascular events at 4000 days (HR, 0.53; 95% CI, 0.32-0.90; P0.02). In addition, ACE I/D gene D allele was associated with higher overall mortality as compared with the I allele (HR, 2.04; P0.003). This effect was diminished in those who received ACE inhibitors. The use of ACE inhibitor was associated with a significant decrease in long-term mortality and cardiovascular events in the patients with DHF. Genetic variants in the renin-angiotensin system genes were also associated, but their effects could be modified by the use of ACE inhibitors. ? 2010 Nature Publishing Group All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
aldosterone; angiotensin; angiotensin 2 receptor; angiotensinogen; beta adrenergic receptor blocking agent; calcium channel blocking agent; cytosine; digoxin; dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase inhibitor; diuretic agent; methionine; nitrate; renin; threonine; thymine; adult; aged; allele; article; controlled study; diastolic heart failure; drug efficacy; drug mechanism; echocardiography; female; gene deletion; gene insertion; genetic polymorphism; genetic variability; human; major clinical study; male; mortality; pharmacogenetics; priority journal; prognosis; renin angiotensin aldosterone system; survival; Aged; Angiotensin-Converting Enzyme Inhibitors; Female; Follow-Up Studies; Gene Deletion; Heart Failure, Diastolic; Humans; Kaplan-Meiers Estimate; Male; Middle Aged; Mutagenesis, Insertional; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Prognosis; Propensity Score; Prospective Studies; Receptors, Angiotensin; Renin-Angiotensin System
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science