https://scholars.lib.ntu.edu.tw/handle/123456789/524331
標題: | Interaction of obesity, metabolic syndrome and Framingham risk on steatohepatitis among healthy Taiwanese: Population-based nested case-control study | 作者: | KUO-LIONG CHIEN Hsu H.-C. CHIA-LUN CHAO BAI-CHIN LEE MING-FONG CHEN Lee Y.-T. |
公開日期: | 2006 | 卷: | 5 | 來源出版物: | Cardiovascular Diabetology | 摘要: | Background: There have been scant reports on the cumulative effects of atherosclerotic risk factors on steatohepatitis. Methods: We defined cases of steatohepatitis (n = 124) from one health examination center at National Taiwan University Hospital from January to December 2002. We selected controls, matched by age, gender and drinking status. Metabolic syndrome was defined by the modified ATP-III guidelines. High-dimensional interactions of risk factors for steatohepatitis were evaluated. Results: Steatohepatitis cases had the highest C-reactive protein, lymphocytes, Framingham scores and predicted coronary risks. The odds ratio (OR) of metabolic syndrome for steatohepatitis was the highest (OR = 9.9), followed by high glucose status (OR = 4.5) and obesity (OR = 3.6). The highest area under the ROC curve was metabolic syndrome (area = 0.80), followed by obesity (0.75) and high glucose level (0.73). Metabolic syndrome was the highest population-attributable risk factor (0.59). Significant interaction was found with a three-factor model, including obesity, metabolic syndrome and Framingham risk status, with lesser average prediction error (22.6%), higher average cross-validation consistency (6.3) and lower average prediction error (24.3%). Compared with persons with no risk factors, OR increased as the number of risk factors increased (OR = 3.0 with one risk factor, 17.5 with two risk factors, 10.8 with three risk factors, respectively). Conclusion: Metabolic syndrome, inflammation markers and atherosclerotic risk scores are significantly related to steatohepatitis status among the healthy examinee population in Taiwan. ? 2006 Chien et al; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745470260&doi=10.1186%2f1475-2840-5-12&partnerID=40&md5=ae12b1fa6818725aafa31d419162a0eb https://scholars.lib.ntu.edu.tw/handle/123456789/524331 |
ISSN: | 1475-2840 | DOI: | 10.1186/1475-2840-5-12 | SDG/關鍵字: | C reactive protein; glucose; adult; age; article; atherosclerosis; case control study; controlled study; coronary risk; drinking behavior; fatty liver; female; gender; human; lymphocyte; major clinical study; male; metabolic syndrome X; obesity; population research; prediction; receiver operating characteristic; risk assessment; risk factor; scoring system; Taiwan; Adult; Asian Continental Ancestry Group; Atherosclerosis; Case-Control Studies; Fatty Liver; Humans; Metabolic Syndrome X; Middle Aged; Models, Statistical; Obesity; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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