https://scholars.lib.ntu.edu.tw/handle/123456789/524942
標題: | High frequency oscillatory ventilation in children: Experience of a Medical Center in Taiwan | 作者: | CHING-CHIA WANG Wu W.-L. EN-TING WU HUNG-CHIEH CHOU FRANK LEIGH LU |
公開日期: | 2008 | 出版社: | Scientific Communications International Ltd | 卷: | 107 | 期: | 4 | 起(迄)頁: | 311-315 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Data about the effectiveness of high frequency oscillatory ventilation (HFOV) in children with respiratory failure are limited. This study investigated the efficacy and prognostic factors of this treatment. Methods: Children between 2 months and 18 years of age who received HFOV between January 2000 and September 2006 in a tertiary care center were enrolled in this retrospective study. Results: Thirty-six HFOV treatments were given to 33 patients (twice in one patient and three times in another patient) at a mean age of 5.4 ± 5.0 years. HFOV was used as a rescue after conventional mechanical ventilation (CMV) for 4.4 ± 4.2 days. The mean duration of HFOV was 7.6 ± 7.9 days. The most common indication for HFOV was oxygenation failure, which was due to pneumonia with acute respiratory distress syndrome in 15 (45.5%), severe lobar pneumonia in nine (27.3%), pulmonary hemorrhage in eight (24.2%) and pneumothorax in one (3%). PaCO2 was significantly improved 4 hours after HFOV and the PaO2/FiO2 ratio increased significantly 12 hours later. The oxygenation index and alveolar-arterial oxygen difference P(A-a)O2, however, did not change markedly. Four (12%) patients needed further extracorporeal life support and two of these survived. The overall survival rate was 45.5%. Patients with heavier body weight (p < 0.05) and of the male gender (p < 0.05) had a higher risk of mortality. Conclusion: As a relatively late rescue therapy after failure of CMV, HFOV may improve PaCO2 and PaO2/FiO2 in children with respiratory failure. However, it carries an increased mortality rate in patients with heavier body weight and male gender. ? 2008 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-43449131829&doi=10.1016%2fS0929-6646%2808%2960092-3&partnerID=40&md5=4a2e4aa9f17f6f00f5c54fa80a8391d0 https://scholars.lib.ntu.edu.tw/handle/123456789/524942 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(08)60092-3 | SDG/關鍵字: | adult respiratory distress syndrome; arterial carbon dioxide tension; arterial oxygen tension; article; artificial ventilation; child; clinical article; controlled study; extracorporeal oxygenation; female; high frequency ventilation; human; lobar pneumonia; lung alveolus oxygen tension; lung hemorrhage; male; mortality; obesity; overall survival; pneumonia; pneumothorax; prognosis; respiratory failure; retrospective study; sex difference; survival rate; Taiwan; tertiary health care; treatment duration; treatment failure; treatment indication |
顯示於: | 醫學系 |
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