https://scholars.lib.ntu.edu.tw/handle/123456789/525005
標題: | Analysis of serum total IgE, specific IgE and eosinophils in children with acute and chronic urticaria | 作者: | Chang K.-L. YAO-HSU YANG HSIN-HUI YU JYH-HONG LEE LI-CHIEH WANG BOR-LUEN CHIANG |
公開日期: | 2013 | 卷: | 46 | 期: | 1 | 起(迄)頁: | 53-58 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/Purpose: Increased IgE and eosinophil levels are frequently observed in cutaneous inflammation and are thought to provoke the occurrence of urticaria. However, the relationship of these factors with the disease duration of urticaria remains unclear. The aim of this study was to compare serum total IgE levels, specific IgE sensitization rates and eosinophil percentages between acute and chronic urticaria in children. Methods: A total of 165 patients (104 with acute and 61 with chronic urticaria) from a tertiary referral hospital were enrolled in this study. Serum levels of total IgE, prevalence of sensitization to food and aeroallergens and blood eosinophil percentages were compared by the disease duration of urticaria. Results: There were no statistical differences in total IgE production, positive sensitization to specific allergens and eosinophil percentages between the patients with acute and chronic urticaria. There is a higher prevalence of sensitization to aeroallergens than food allergens in children with urticaria. In terms of gender, males had significantly higher serum IgE levels than females. Conclusion: Boys potentially have a higher serum IgE expression than girls children with urticaria. IgE levels and eosinophil percentages are not good indicators for a prolonged course of urticaria. The prevalence of sensitization to aeroallergens was significantly higher than that of food allergens in children with urticaria. Routine laboratory analysis for common allergens is not appropriate, and it could be a feasible approach to detect a predilection for atopy when respiratory infections are causative factors of urticaria occurrence. ? 2011. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872604372&doi=10.1016%2fj.jmii.2011.12.030&partnerID=40&md5=cf562e36455bf837872d9ec09e1e04b5 https://scholars.lib.ntu.edu.tw/handle/123456789/525005 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2011.12.030 | SDG/關鍵字: | allergen; immunoglobulin E; acute disease; adolescent; antibody blood level; article; child; chronic disease; disease duration; eosinophil; female; human; major clinical study; male; preschool child; prevalence; school child; sex difference; urticaria; Adolescent; Allergens; Child; Child, Preschool; Eosinophils; Female; Humans; Hypersensitivity; Immunoglobulin E; Infant; Leukocyte Count; Male; Prevalence; Serum; Tertiary Care Centers; Urticaria |
顯示於: | 醫學系 |
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