https://scholars.lib.ntu.edu.tw/handle/123456789/525006
標題: | Association between human IL-10 gene polymorphisms and serum IL-10 level in patients with food allergy | 作者: | Chen T.-K. JYH-HONG LEE HSIN-HUI YU YAO-HSU YANG LI-CHIEH WANG YU-TSAN LIN BOR-LUEN CHIANG |
公開日期: | 2012 | 卷: | 111 | 期: | 12 | 起(迄)頁: | 686-692 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Single nucleotide polymorphisms (SNPs) of the interleukin-10 (IL-10) gene are associated with allergic diseases in different populations. This study aimed to determine the distribution of two SNPs at -1082A/G and -592A/C (rs1800896 and rs1800872, respectively) in the IL-10 gene promoter of Taiwanese food allergy (FA) patients, and also to compare the serum IL-10 levels between patients with (FA) and controls. Methods: Thirty-seven patients with FA and 52 controls were enrolled, and their peripheral blood was collected for IL-10 SNP genotyping and the corresponding serum IL-10 level of each genotype. Results: The thirty-seven FA patients had positive food-specific IgE (? 0.75. kU/L) to more than one food, and the most frequent allergens wereshrimp and crab (56.8% and 35.1%, respectively). The genotype distributions in the FA patients compared to the control group were AA and AG at -1082A/G (86.5% and 13.5% vs. 86.6% and 13.4%, respectively), and AA, AC, and CC at -592A/C (45.9%, 43.3% and 10.8% vs. 38.5%, 48.1% and 13.4%, respectively). Serum IL-10 levels were significantly lower in the FA group than in the control group (p= 0.0187), and the IL-10 level of -592A/C of genotype AA was significantly lower than that of the other genotypes (AC+CC) (p= 0.007). Patients with AA/AA haplotype homozygotes (10 of 24) had significantly lower serum IL-10 levels than those with other haplotypes. Conclusions: The two SNPs at -1082A/G and -592A/C of IL-10 were associated with FA in our Taiwanese population, and FA patients with the genotype AA/AA haplotype homozygotes had lower serum IL-10 levels. This suggests that IL-10 might play a critical role in the pathogenesis of FA. We suggest that it may be practicable to evaluate the serum IL-10 levels of FA patients and to predict the possibility of FA if genotypes and haplotypes are checked regularly. ? 2012 . |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871607477&doi=10.1016%2fj.jfma.2011.11.027&partnerID=40&md5=ddebd5e28fa5b19aebb89cf934898404 https://scholars.lib.ntu.edu.tw/handle/123456789/525006 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2011.11.027 | SDG/關鍵字: | food allergen; immunoglobulin E; interleukin 10; adolescent; adult; article; blood; child; clinical article; controlled study; crab; female; food allergy; genetic association; genotype; haplotype; homozygote; human; infant; male; preschool child; promoter region; school child; shrimp; single nucleotide polymorphism; Taiwan; Adolescent; Adult; Asian Continental Ancestry Group; Child; Child, Preschool; Female; Food Hypersensitivity; Haplotypes; Humans; Infant; Interleukin-10; Male; Middle Aged; Polymorphism, Single Nucleotide; Taiwan; Young Adult |
顯示於: | 醫學系 |
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