In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds
Journal
Biomaterials
Journal Volume
145
Pages
1-8
Date Issued
2017
Author(s)
Abstract
Patients with diabetes mellitus are prone to develop refractory wounds. They exhibit reduced synthesis and levels of circulating hydrogen sulfide (H2S), which is an ephemeral gaseous molecule. Physiologically, H2S is an endogenous gasotransmitter with multiple biological functions. An emulsion method is utilized to prepare a microparticle system that comprises phase-change materials with a nearly constant temperature of phase transitions to encapsulate sodium hydrosulfide (NaHS), a highly water-labile H2S donor. An emulsion technique that can minimize the loss of water-labile active compounds during emulsification must be developed. The as-prepared microparticles (NaHS@MPs) provide an in situ depot for the sustained release of exogenous H2S under physiological conditions. The sustained release of H2S promotes several cell behaviors, including epidermal/endothelial cell proliferation and migration, as well as angiogenesis, by extending the activation of cellular ERK1/2 and p38, accelerating the healing of full-thickness wounds in diabetic mice. These experimental results reveal the strong potential of NaHS@MPs for the sustained release of H2S for the treatment of diabetic wounds. ? 2017 Elsevier Ltd
Subjects
Angiogenesis; Drug delivery; Gasotransmitter; Hydrogen sulfide; Refractory wound
Other Subjects
gasotransmitter; hydrogen sulfide; microsphere; angiogenesis; animal; cell motion; cell proliferation; drug effect; experimental diabetes mellitus; human; mouse; pathology; umbilical vein endothelial cell; wound healing; Animals; Cell Movement; Cell Proliferation; Diabetes Mellitus, Experimental; Gasotransmitters; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Sulfide; Mice; Microspheres; Neovascularization, Physiologic; Wound Healing
Publisher
Elsevier Ltd
Type
journal article