https://scholars.lib.ntu.edu.tw/handle/123456789/525211
標題: | Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection | 作者: | Korupalli C. Huang C.-C. Lin W.-C. Pan W.-Y. Lin P.-Y. Wan W.-L. MENG-JU LI Chang Y. Sung H.-W. |
關鍵字: | Charge conversion; Imaging guiding; pH-responsive nanoparticles; Photothermal therapy; Subcutaneous abscesses | 公開日期: | 2017 | 出版社: | Elsevier Ltd | 卷: | 116 | 起(迄)頁: | 1-9 | 來源出版物: | Biomaterials | 摘要: | Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5?°C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections. ? 2016 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84998979436&doi=10.1016%2fj.biomaterials.2016.11.045&partnerID=40&md5=be371a92f449e8028d6629e4c184d64f https://scholars.lib.ntu.edu.tw/handle/123456789/525211 |
ISSN: | 0142-9612 | DOI: | 10.1016/j.biomaterials.2016.11.045 | SDG/關鍵字: | Ablation; Conjugated polymers; Infrared devices; Nanoparticles; Polyaniline; Tissue; Amphiphilic polymers; Antibiotic-resistant bacteria; Imaging guiding; Near infrared region; PH-responsive; Photothermal ablation; Photothermal therapy; Subcutaneous abscesses; Bacteria; chitosan; glycol; nanoparticle; polyaniline; nanoparticle; ablation therapy; acidity; animal experiment; animal model; animal tissue; Article; bacterial viability; bacterium adherence; conjugation; controlled study; Escherichia coli; heating; host cell; infection; methicillin resistant Staphylococcus aureus; mouse; nonhuman; photothermal therapy; priority journal; surface charge; temperature sensitivity; tissue injury; wound healing; animal; bacterial infection; bacterial phenomena and functions; Bagg albino mouse; cell survival; chemistry; heat; light; pathology; pH; phototherapy; procedures; radiation response; static electricity; thermotherapy; treatment outcome; Animals; Bacterial Infections; Bacterial Physiological Phenomena; Cell Survival; Hot Temperature; Hydrogen-Ion Concentration; Hyperthermia, Induced; Light; Mice; Mice, Inbred BALB C; Nanoparticles; Phototherapy; Static Electricity; Treatment Outcome |
顯示於: | 醫學系 |
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