Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection
Journal
Biomaterials
Journal Volume
116
Pages
1-9
Date Issued
2017
Author(s)
Abstract
Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5?°C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections. ? 2016 Elsevier Ltd
Subjects
Charge conversion; Imaging guiding; pH-responsive nanoparticles; Photothermal therapy; Subcutaneous abscesses
SDGs
Other Subjects
Ablation; Conjugated polymers; Infrared devices; Nanoparticles; Polyaniline; Tissue; Amphiphilic polymers; Antibiotic-resistant bacteria; Imaging guiding; Near infrared region; PH-responsive; Photothermal ablation; Photothermal therapy; Subcutaneous abscesses; Bacteria; chitosan; glycol; nanoparticle; polyaniline; nanoparticle; ablation therapy; acidity; animal experiment; animal model; animal tissue; Article; bacterial viability; bacterium adherence; conjugation; controlled study; Escherichia coli; heating; host cell; infection; methicillin resistant Staphylococcus aureus; mouse; nonhuman; photothermal therapy; priority journal; surface charge; temperature sensitivity; tissue injury; wound healing; animal; bacterial infection; bacterial phenomena and functions; Bagg albino mouse; cell survival; chemistry; heat; light; pathology; pH; phototherapy; procedures; radiation response; static electricity; thermotherapy; treatment outcome; Animals; Bacterial Infections; Bacterial Physiological Phenomena; Cell Survival; Hot Temperature; Hydrogen-Ion Concentration; Hyperthermia, Induced; Light; Mice; Mice, Inbred BALB C; Nanoparticles; Phototherapy; Static Electricity; Treatment Outcome
Publisher
Elsevier Ltd
Type
journal article