https://scholars.lib.ntu.edu.tw/handle/123456789/525240
標題: | Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries | 作者: | Moons P. Luyckx K. Thomet C. Budts W. Enomoto J. Sluman M.A. CHUN-WEI LU Jackson J.L. Khairy P. Cook S.C. Chidambarathanu S. Alday L. Eriksen K. Dellborg M. Berghammer M. Johansson B. Mackie A.S. Menahem S. Caruana M. Veldtman G. Soufi A. Fernandes S.M. White K. Callus E. Kutty S. Ombelet F. Apers S. Kovacs A.H. APPROACH-IS Consortium the International Society for Adult Congenital Heart Disease (ISACHD) |
公開日期: | 2020 | 出版社: | Elsevier Inc. | 來源出版物: | Canadian Journal of Cardiology | 摘要: | Background: We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods: In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale, respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions: Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes. ? 2020 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089458390&doi=10.1016%2fj.cjca.2020.03.044&partnerID=40&md5=6ddab47a577c02a860442d921e56a1ea https://scholars.lib.ntu.edu.tw/handle/123456789/525240 |
ISSN: | 0828-282X | DOI: | 10.1016/j.cjca.2020.03.044 | SDG/關鍵字: | adult; aortic coarctation; Article; clinical outcome; congenital heart malformation; controlled study; cross-sectional study; cyanotic heart disease; data analysis software; Eisenmenger complex; female; functional status; health status; Hospital Anxiety and Depression Scale; human; major clinical study; male; mental health; New York Heart Association class; patient-reported outcome; physical activity; quality of life; Satisfaction with Life Scale; Short Form 12 |
顯示於: | 醫學系 |
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