https://scholars.lib.ntu.edu.tw/handle/123456789/525270
標題: | Arrhythmic burdens in patients with tetralogy of Fallot: A national database study | 作者: | MEI-HWAN WU CHUN-WEI LU Chen H.-C. SHUENN-NAN CHIU Kao F.-Y. Huang S.-K. |
公開日期: | 2015 | 出版社: | Elsevier | 卷: | 12 | 期: | 3 | 起(迄)頁: | 604-609 | 來源出版物: | Heart Rhythm | 摘要: | Background Tetralogy of Fallot (TOF) is a common cyanotic congenital heart disease with increasingly recognized late morbidity. Objective The purpose of this study was to explore the long-term outcome by using a national database of Taiwan, a country with national health insurance and easily accessible medical care. Methods Data on TOF patients were retrieved from database records from 2000 to 2010. Complications and therapies were identified by their respective codes. Results We identified 4781 TOF patients (prevalence 0.63/1000 in pediatric patients and 0.06/1000 in adult patients). Arrhythmias were identified in 219 patients (8.3% for adult patients and 2.8% for pediatric patients): 160 tachycardia and 59 bradycardia (4 with tachy-bradycardia syndrome). The occurrence of arrhythmias was associated with higher mortality (excluding cardiac surgical death, 15.6% vs 8.6%, P =.001). Patients with atrial fibrillation were the oldest (median age 44.3 years), followed by those with tachy-bradycardia syndromes (32.4 years) and atrial flutter (31.5 years). The incidence of nonperioperative tachycardia increased with age (1.4%, 1.7%, 3.3%, 5.2%, 10.2%, and 16.9% in age group 0-9, 10-19, 20-29, 30-39, 40-49, and ?50 years, respectively). Tachycardia therapy (ablation and implantable cardioverter-defibrillator) was administered in 20.4% (annually 2.4%) of patients with nonperioperative tachycardia. In the subgroup born 2000-2010 with complete postnatal data, mortality was 15.1% (296/1960), and 1-, 5-, and 10-year survival was 0.911, 0.826, and 0.788, respectively. Risk of atrioventricular block requiring a pacemaker was 0.6%. Conclusion Arrhythmias are common in TOF patients and increase mortality risk. Medical needs because of tachycardia often appear late in adulthood. ? 2015 Heart Rhythm Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924047749&doi=10.1016%2fj.hrthm.2014.11.026&partnerID=40&md5=4d6b384c0c171a9f85aa465e84a0f932 https://scholars.lib.ntu.edu.tw/handle/123456789/525270 |
ISSN: | 1547-5271 | DOI: | 10.1016/j.hrthm.2014.11.026 | SDG/關鍵字: | ablation therapy; adult; Article; atrioventricular block; bradycardia; cardiovascular risk; cohort analysis; Fallot tetralogy; female; health care need; heart atrium flutter; human; implantable cardioverter defibrillator; incidence; major clinical study; male; medical care; mortality; national health insurance; outcome assessment; prevalence; priority journal; tachycardia; Taiwan; adolescent; aged; aging; Arrhythmias, Cardiac; artificial heart pacemaker; atrial fibrillation; Atrial Flutter; bradycardia; child; complication; cost of illness; economics; Fallot tetralogy; middle aged; preschool child; statistics and numerical data; tachycardia; young adult; Adolescent; Adult; Aged; Aging; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardia; Child; Child, Preschool; Cost of Illness; Defibrillators, Implantable; Female; Humans; Incidence; Male; Middle Aged; Pacemaker, Artificial; Tachycardia; Taiwan; Tetralogy of Fallot; Young Adult |
顯示於: | 醫學系 |
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