Epidemiological profile of Wolff-Parkinson-White syndrome in a general population younger than 50 years of age in an era of radiofrequency catheter ablation
Journal
International Journal of Cardiology
Journal Volume
174
Journal Issue
3
Pages
530-534
Date Issued
2014
Author(s)
Abstract
Background The prevalence of Wolff-Parkinson-White (WPW) syndrome varies between 0.68 and 1.7/1000. The epidemiological profile may be modified after the introduction of transcatheter interventions. Objectives The aim of this study is to investigate the epidemiological trends of the WPW syndrome in a general population during a period with available and reimbursed transcatheter ablation. Methods and results Data of WPW patients < 50 years old were retrieved from our national database (2000-2010). We identified 6086 (61% male) patients, accounting for an overall prevalence of 0.36/1000 with a peak of 0.61/1000 in ages 20-24 years. The risk of death and sudden death was 0.071% and 0.02% per patient-year, respectively. The 42 deaths occurred at a median age of 29 years. Associated congenial heart disease was noted in 158 (2.6%) patients, including 42 with Ebstein's anomaly that increased the mortality risk (P = 0.001, OR = 8.5). In those without congenital heart disease, myocardial dysfunction occurred in 115 (1.9%) patients and increased the risk of death (P < 0.001, OR = 10.6) and sudden death. Radiofrequency catheter ablation was performed in 2527 patients at a median age of 25.7 years (4.54% per patient-year, discharge mortality 0.16%); 11 (0.4%) before the age of 5, and 2231 (88%) after the age of 15. Whereas repeated ablation procedures accounted for 6.0% of the procedures, those in Ebstein's patients were 25%. Conclusion Radiofrequency catheter ablation is already a common treatment for WPW patients, particularly during young adulthood, which accounts for a lower prevalence. Myocardial dysfunction and associated congenital heart disease remain as risks of mortality. ? 2014 Elsevier Ireland Ltd.
SDGs
Other Subjects
adolescent; adult; age distribution; article; cardiovascular mortality; cardiovascular risk; catheter ablation; child; cohort analysis; congenital heart disease; disease association; Ebstein anomaly; epidemiological data; female; high risk population; human; major clinical study; male; middle aged; myocardial disease; newborn; preschool child; prevalence; priority journal; retrospective study; risk assessment; school child; sudden death; trend study; Wolff Parkinson White syndrome; young adult; catheter ablation; health survey; infant; International Classification of Diseases; procedures; Taiwan; trends; Wolff-Parkinson-White Syndrome; Adolescent; Adult; Catheter Ablation; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; International Classification of Diseases; Male; Middle Aged; Population Surveillance; Retrospective Studies; Taiwan; Wolff-Parkinson-White Syndrome; Young Adult
Publisher
Elsevier Ireland Ltd
Type
journal article