https://scholars.lib.ntu.edu.tw/handle/123456789/525461
標題: | Significance of Symptom Clustering in Palliative Care of Advanced Cancer Patients | 作者: | JAW-SHIUN TSAI Wu C.-H. TAI-YUAN CHIU Chen C.-Y. |
公開日期: | 2010 | 卷: | 39 | 期: | 4 | 起(迄)頁: | 655-662 | 來源出版物: | Journal of Pain and Symptom Management | 摘要: | Patients with advanced cancer often experience multiple concurrent symptoms. To explore this symptom clustering and its associated parameters, we prospectively surveyed 427 consecutive patients on admission to the Palliative Care Unit. There were 222 males (52.0%) and 205 females (48.0%), with a median age of 66 years (range: 27-93 years). The main tumor sites were lung (19.9%), liver (18.0%), and colorectum (11.0%). The median survival was 13 days (1-418 days). Symptoms were assessed using a face-valid Symptom Reporting Form. We identified five symptom clusters by exploratory factor analysis. Clusters were named "loss of energy," "poor intake," "autonomic dysfunction," "aerodigestive impairment," and "pain complex." We used nonhierarchical cluster analysis to divide the 394 patients with complete data into six groups. Each group was characterized by a particular pattern that was composed of different symptom clusters. Survival, functional performance, bone metastasis, and fluid accumulation were significantly associated with symptom clustering in six groups of patients. The severity of psychological distress also related to their physical deterioration. These data suggest that different underlying mechanisms associate with symptom clustering. Further elucidation of these processes may assist in symptom management. ? 2010 U.S. Cancer Pain Relief Committee. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77951002651&doi=10.1016%2fj.jpainsymman.2009.09.005&partnerID=40&md5=d661c94923af64a8c5d6521d8cdfbe1b https://scholars.lib.ntu.edu.tw/handle/123456789/525461 |
ISSN: | 0885-3924 | DOI: | 10.1016/j.jpainsymman.2009.09.005 | SDG/關鍵字: | adult; advanced cancer; aged; aggression; anorexia; anxiety; article; bone metastasis; cancer palliative therapy; cancer patient; cancer survival; clinical assessment; clinical feature; cluster analysis; colorectal tumor; constipation; depression; diarrhea; disease severity; distress syndrome; dizziness; dysphagia; dyspnea; exploratory research; factorial analysis; fatigue; female; hospital admission; human; insomnia; liver tumor; lung tumor; major clinical study; male; nausea and vomiting; night sweat; pain; prospective study; restlessness; symptomatology; taste disorder; tumor localization; weakness; xerostomia; Adult; Aged; Aged, 80 and over; Cluster Analysis; Comorbidity; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Palliative Care; Prevalence; Risk Assessment; Risk Factors; Sensitivity and Specificity; Survival Analysis; Survival Rate; Taiwan |
顯示於: | 醫學系 |
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