https://scholars.lib.ntu.edu.tw/handle/123456789/525490
標題: | Pneumocystis jiroveci pneumonia in Taiwan from 2014 to 2017: Clinical manifestations and outcomes between pediatric and adult patients | 作者: | Lee H.-Y. CHUN-YI LU PING-ING LEE JONG-MIN CHEN LI-MIN HUANG LUAN-YIN CHANG |
公開日期: | 2019 | 出版社: | Elsevier Ltd | 卷: | 52 | 期: | 6 | 起(迄)頁: | 983-990 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background: Pneumocystis jiroveci pneumonia (PJP) is a severe and lethal opportunistic infection in the immunocompromised patients. As the increasing usage of immunosuppressants, the incidence of non-HIV related PJP has increased in recent years. Still, there is little research regarding children with PJP. The aim of this study is to understand PJP more among pediatric population. Methods: We reviewed the medical records of the patients with PJP in National Taiwan University Hospital from 2014 to 2017. Diagnosis was made if the patient met all of the criteria: presence of relevant pulmonary symptoms and signs, pulmonary infiltrates on images, detection of Pneumocystis jiroveci from respiratory specimens via polymerase chain reaction (PCR), and received antibiotics for PJP. Results: Twenty children and 132 adults were enrolled in this study. The most common underlying diseases among children included malignancy (40%), post-transplantation (30%), and primary immunodeficiency (20%). The major underlying diseases in adults included malignancy (36%), HIV with acquired immunodeficiency syndrome (AIDS) (31%), and autoimmune diseases (24%). There is no significant difference in the clinical manifestations, mortality, and complication between children and adults, but children tended to have less chance of using alternative antibiotics, methylprednisolone and inhaled nitric oxide (NO). The chance of concomitant cytomegalovirus disease was also significantly lower in pediatric patients. Conclusion: No significant difference was found in the clinical manifestations, mortality, and complication between children and adults, but children tended to have lesser chance of using alternative antibiotics, methylprednisolone and inhaled NO. The chance of associated cytomegalovirus (CMV) disease was also significantly lower in children. ? 2019 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066314732&doi=10.1016%2fj.jmii.2019.05.003&partnerID=40&md5=28f8a7bd2e53e5e71d561a4cbf5df6e9 https://scholars.lib.ntu.edu.tw/handle/123456789/525490 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2019.05.003 | SDG/關鍵字: | antibiotic agent; antineoplastic agent; corticosteroid; cotrimoxazole; methylprednisolone; nitric oxide; antiinfective agent; acquired immune deficiency syndrome; acute kidney failure; adult; antibiotic prophylaxis; antibiotic therapy; Article; artificial ventilation; autoimmune disease; bloodstream infection; bronchoalveolar lavage fluid; cancer chemotherapy; child; childhood cancer; clinical feature; coughing; cytomegalovirus infection; disease association; dyspnea; extracorporeal oxygenation; female; fever; gastrointestinal hemorrhage; hepatitis; human; Human immunodeficiency virus infection; hyperkalemia; hyponatremia; immune deficiency; lung infiltrate; lymphocyte count; major clinical study; male; medical record review; outcome assessment; Pneumocystis pneumonia; pneumothorax; polymerase chain reaction; respiratory failure; retrospective study; symptom; Taiwan; vomiting; adolescent; age; aged; comparative study; immunocompromised patient; infant; medical record; microbiology; middle aged; mortality; Pneumocystis pneumonia; preschool child; sputum; treatment outcome; very elderly; young adult; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Child; Child, Preschool; Female; Humans; Immunocompromised Host; Infant; Male; Medical Records; Middle Aged; Pneumonia, Pneumocystis; Retrospective Studies; Sputum; Taiwan; Treatment Outcome; Young Adult |
顯示於: | 醫學系 |
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