Human parvovirus B19 infection in patients with or without underlying diseases
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
52
Journal Issue
4
Pages
534-541
Date Issued
2019
Author(s)
Abstract
Background/Purpose: The clinical presentations of parvovirus B19 in patients with underlying diseases have greater diversity than previously healthy patients. We retrospectively identified patients with polymerase chain reaction (PCR)-confirmed parvovirus B19 infection in attempt to describe its clinical features especially in these populations. Methods: From 2009 to 2018, patients with real-time PCR-confirmed parvovirus B19 infection were collected. Comparisons were done between previously healthy patients and patients with preexisting diseases, as well as patients with high (>5.5 × 105 copies/mL sera) and low viral loads. Results: Parvovirus B19 DNA was detected in 31 patients. Fourteen (45%) patients had underlying diseases, including six (19%) with immunologic diseases, five (16%) with hematologic diseases, and three (10%) with cardiopulmonary diseases. Only seven (23%) patients received an initial impression of erythema infectiosum prior to positive PCR. A higher proportion of patients with underlying diseases presented with fatigue and pallor, and suffered from tachycardia and hepatosplenomegaly compared to previously healthy patients. Among patients with a high viral load, a substantial proportion were of older age, suffered fatigue, and anemia. There was a trend of patients with immunologic comorbidity having a higher viral load. Conclusion: The classical parvovirus B19 manifestations were less frequently observed in patients with a preexisting disease compared with previously healthy patients. Depending on host factors, the symptoms of parvovirus B19 infection can be multifaceted. ? 2019
SDGs
Other Subjects
virus DNA; virus DNA; adolescent; adult; aged; anemia; Article; blood cell count; child; clinical article; clinical feature; comorbidity; comparative study; DNA extraction; erythema infectiosum; female; hepatosplenomegaly; hospitalization; human; Human parvovirus B19; immunosuppressive treatment; male; nonhuman; pallor; polymerase chain reaction; population; real time polymerase chain reaction; retrospective study; tachycardia; virus load; blood; complication; erythema infectiosum; fatigue; genetics; Human parvovirus B19; infant; isolation and purification; middle aged; preschool child; season; serology; serum; Taiwan; virology; young adult; Adolescent; Adult; Anemia; Child; Child, Preschool; DNA, Viral; Erythema Infectiosum; Fatigue; Female; Humans; Infant; Male; Middle Aged; Parvovirus B19, Human; Polymerase Chain Reaction; Retrospective Studies; Seasons; Serologic Tests; Serum; Tachycardia; Taiwan; Viral Load; Young Adult
Publisher
Elsevier Ltd
Type
journal article