|Title:||Severe bacterial infection in patients with heterotaxy syndrome||Authors:||SHUENN-NAN CHIU
|Issue Date:||2014||Publisher:||Mosby Inc.||Journal Volume:||164||Journal Issue:||1||Start page/Pages:||99-104||Source:||Journal of Pediatrics||Abstract:||
Objective To determine the incidence of sepsis in patients with heterotaxy syndrome. Study design From our institutional database, we identified patients with heterotaxy syndrome and other complex congenital heart disease (CHD) born between 2001 and 2011. Severe bacterial infection was defined as sepsis with positive culture result or infection with abscess formation. Results We enrolled 95 patients with heterotaxy syndrome (88 with right atrial isomerism and 7 with left atrial isomerism) and 142 patients with complex CHD. With 1026 person-years follow-up, the 5-year survival was 52% and 65.7% in heterotaxy and complex CHD groups, respectively (P =.239). Community-acquired severe bacterial infection occurred only in heterotaxy syndrome (13 episodes in 10 patients, 3 of whom had spleen noted at imaging study) with 2- and 5 years cumulative severe bacterial infection rate of 9.6% and 14.5%, respectively. The overall mortality rate of those with community-acquired severe bacterial infection was 31%. Pneumococcus and Citrobacter freundii were the most common pathogens. Nosocomial severe bacterial infection occurred in 33.3% of all patients and 12.5% of all procedures. The rates (0.59 and 0.52/100 hospitalization days in heterotaxy and complex CHD group) and the pathogens of nosocomial severe bacterial infection were similar between heterotaxy and complex CHD groups. Conclusions Patients with heterotaxy syndrome are at high risk for community-acquired severe bacterial infection and also have high mortality rate whether the spleen is present or not. The risk of nosocomial severe bacterial infection seems similar to that of patients with other complex CHD. ? Copyright 2014 Mosby Inc. All rights reserved.
|ISSN:||0022-3476||DOI:||10.1016/j.jpeds.2013.08.051||SDG/Keyword:||article; bacterial infection; Candida; child; Citrobacter freundii; coagulase negative Staphylococcus; controlled study; Enterobacter cloacae; female; follow up; heterotaxy syndrome; hospitalization; human; incidence; isomerism; Klebsiella; major clinical study; male; mortality; perinatal infection; preschool child; priority journal; Pseudomonas; spleen; Staphylococcus aureus; Stenotrophomonas; Streptococcus pneumoniae; survival rate; survival time
|Appears in Collections:||醫學系|
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