The genetics of atopic dermatitis
Journal
Clinical Reviews in Allergy and Immunology
Journal Volume
33
Journal Issue
3
Pages
178-190
Date Issued
2007
Author(s)
Abstract
Background: Atopic dermatitis (AD) is a complex genetic disorder influenced by environmental factors. The mode of inheritance and genes involved are not clear. Results: This report here is focusing on the current progress in searching the disease-susceptibility genes of AD via both the linkage studies and candidate gene approaches. Genome-wide linkage studies have identified multiple susceptibility loci on 3q and 17q. Candidate region linkage studies identify other susceptibility loci on 5q23-33, 11q13, and 13q12-14. At least 28 candidate genes have to date been verified in association studies, but only association with genes of interleukin (IL)-4, IL-13, IL-4RA, mast cell chymase, and serine protease inhibitor, kazal-type 5 have been replicated in more than two different studies. More halpotype tests and family-based association studies may help to shed more light for the candidate gene approach. Conclusion: Determining the candidate susceptibility genes for AD is not only helping understanding the pathophysiology but also affecting the response to therapy, which is important in pharmacogenetics. The effect of environmental trigger may also have to be considered to elucidate the real face of the disease. ? 2007 Humana Press Inc.
Other Subjects
arylamine acetyltransferase; caspase recruitment domain protein 15; CD14 antigen; chemokine receptor CCR3; chemokine receptor CCR4; chymase; eotaxin; granulocyte macrophage colony stimulating factor; immunoglobulin E receptor; interferon regulatory factor 2; interleukin 10; interleukin 12p40; interleukin 13; interleukin 18; interleukin 4; interleukin 4 receptor alpha; interleukin 5; monocyte chemotactic protein 1; RANTES; serine proteinase inhibitor; STAT6 protein; thymus and activation regulated chemokine; toll like receptor 2; transforming growth factor beta1; zinc finger protein; atopic dermatitis; disease predisposition; gene frequency; gene locus; genetic association; genetic linkage; genetic polymorphism; genetic susceptibility; genetic variability; human; nonhuman; review; Child; Child, Preschool; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 5; Dermatitis, Atopic; Female; Genetic Predisposition to Disease; Humans; Immunologic Factors; Interleukin-4; Linkage (Genetics); Male; Polymorphism, Genetic; Pregnancy; Receptors, Interleukin-4
Type
review