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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/526374
Title: The Impact of Hepatitis on Clinical Outcomes for Pediatric Patients with Aplastic Anemia
Authors: Wang W.-H.
JIA-FENG WU 
HSIU-HAO CHANG 
MENG-YAO LU 
YUNG-LI YANG 
SHU-WEI CHOU 
Lin D.-T.
Lin K.-H.
SHIANN-TANG JOU 
Issue Date: 2020
Publisher: Mosby Inc.
Journal Volume: 227
Start page/Pages: 87-9300
Source: Journal of Pediatrics
Abstract: 
Objectives: To assess the prognostic role of hepatitis in pediatric patients with aplastic anemia and the incidence of hepatitis B among patients with hepatitis-associated aplastic anemia in an area with a previously high prevalence of hepatitis B after nationwide hepatitis B vaccination for 30 years. Study design: Pediatric patients (n = 78) with aplastic anemia were enrolled in this study, including 9 with hepatitis-associated aplastic anemia. We collected the clinical characteristics, etiologies of the aplastic anemia, hepatitis B virus serology and serum hepatitis B viral load, response to the treatments, and survival outcome from the participants. We applied univariate and multivariate Cox regression analysis to evaluate the correlations between clinical features and survival outcome. Survival analysis was done using Cox regression model and Kaplan-Meier curves. Results: Patients with hepatitis-associated aplastic anemia were related to significantly worse survival prognosis when compared with patients with non-hepatitis-associated aplastic anemia, and hepatitis-associated aplastic anemia was the only independent prognostic factor to predict a poor survival outcome in our patients with aplastic anemia by multivariable analysis. In none of the total 78 patients was aplastic anemia related to hepatitis B virus infection. Conclusions: Patients with hepatitis-associated aplastic anemia had a significantly worse prognosis when compared with patients whose aplastic anemia was not hepatitis-associated. This study demonstrates the potential benefit of hepatitis B vaccination in decreasing the incidence of hepatitis-associated aplastic anemia in children. ? 2020 Elsevier Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091898183&doi=10.1016%2fj.jpeds.2020.08.028&partnerID=40&md5=e8f5368d7db9b8eb48b2c8102b7a9f5e
https://scholars.lib.ntu.edu.tw/handle/123456789/526374
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2020.08.028
SDG/Keyword: antibiotic agent; cyclosporine; thymocyte antibody; immunosuppressive agent; adolescent; aplastic anemia; Article; child; clinical feature; clinical outcome; controlled study; female; hepatitis B; human; immunosuppressive treatment; major clinical study; male; pediatric patient; priority journal; prognosis; survival; treatment response; virus load; aplastic anemia; blood; case control study; complication; hepatitis B; Hepatitis B virus; infant; isolation and purification; Kaplan Meier method; mortality; newborn; preschool child; proportional hazards model; severity of illness index; Taiwan; virology; Adolescent; Anemia, Aplastic; Case-Control Studies; Child; Child, Preschool; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Kaplan-Meier Estimate; Proportional Hazards Models; Severity of Illness Index; Taiwan
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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