https://scholars.lib.ntu.edu.tw/handle/123456789/526374
標題: | The Impact of Hepatitis on Clinical Outcomes for Pediatric Patients with Aplastic Anemia | 作者: | Wang W.-H. JIA-FENG WU HSIU-HAO CHANG MENG-YAO LU YUNG-LI YANG SHU-WEI CHOU Lin D.-T. Lin K.-H. SHIANN-TANG JOU |
公開日期: | 2020 | 出版社: | Mosby Inc. | 卷: | 227 | 起(迄)頁: | 87-9300 | 來源出版物: | Journal of Pediatrics | 摘要: | Objectives: To assess the prognostic role of hepatitis in pediatric patients with aplastic anemia and the incidence of hepatitis B among patients with hepatitis-associated aplastic anemia in an area with a previously high prevalence of hepatitis B after nationwide hepatitis B vaccination for 30 years. Study design: Pediatric patients (n = 78) with aplastic anemia were enrolled in this study, including 9 with hepatitis-associated aplastic anemia. We collected the clinical characteristics, etiologies of the aplastic anemia, hepatitis B virus serology and serum hepatitis B viral load, response to the treatments, and survival outcome from the participants. We applied univariate and multivariate Cox regression analysis to evaluate the correlations between clinical features and survival outcome. Survival analysis was done using Cox regression model and Kaplan-Meier curves. Results: Patients with hepatitis-associated aplastic anemia were related to significantly worse survival prognosis when compared with patients with non-hepatitis-associated aplastic anemia, and hepatitis-associated aplastic anemia was the only independent prognostic factor to predict a poor survival outcome in our patients with aplastic anemia by multivariable analysis. In none of the total 78 patients was aplastic anemia related to hepatitis B virus infection. Conclusions: Patients with hepatitis-associated aplastic anemia had a significantly worse prognosis when compared with patients whose aplastic anemia was not hepatitis-associated. This study demonstrates the potential benefit of hepatitis B vaccination in decreasing the incidence of hepatitis-associated aplastic anemia in children. ? 2020 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091898183&doi=10.1016%2fj.jpeds.2020.08.028&partnerID=40&md5=e8f5368d7db9b8eb48b2c8102b7a9f5e https://scholars.lib.ntu.edu.tw/handle/123456789/526374 |
ISSN: | 0022-3476 | DOI: | 10.1016/j.jpeds.2020.08.028 | SDG/關鍵字: | antibiotic agent; cyclosporine; thymocyte antibody; immunosuppressive agent; adolescent; aplastic anemia; Article; child; clinical feature; clinical outcome; controlled study; female; hepatitis B; human; immunosuppressive treatment; major clinical study; male; pediatric patient; priority journal; prognosis; survival; treatment response; virus load; aplastic anemia; blood; case control study; complication; hepatitis B; Hepatitis B virus; infant; isolation and purification; Kaplan Meier method; mortality; newborn; preschool child; proportional hazards model; severity of illness index; Taiwan; virology; Adolescent; Anemia, Aplastic; Case-Control Studies; Child; Child, Preschool; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Kaplan-Meier Estimate; Proportional Hazards Models; Severity of Illness Index; Taiwan |
顯示於: | 醫學系 |
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