https://scholars.lib.ntu.edu.tw/handle/123456789/526392
標題: | Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group | 作者: | Chen S.-H. Chen J.-S. SHIANN-TANG JOU Wu K.-H. Hung I.-J. Sheen J.-M. MENG-YAO LU Chen B.-W. Jaing T.-H. Wang S.-C. Lin M.-T. Chang T.-K. Liu H.-C. Yang C.-P. |
公開日期: | 2019 | 出版社: | Taylor and Francis Ltd | 卷: | 60 | 期: | 8 | 起(迄)頁: | 1942-1949 | 來源出版物: | Leukemia and Lymphoma | 摘要: | Studies of childhood anaplastic large cell lymphoma (ALCL) are less reported from East Asian countries. Clinical features and outcome of 90 children with ALCL in Taiwan were analyzed. The median age at diagnosis was 11.7 years. The most common presentation was lymph node involvement (86.7%). Advanced diseases accounted for 70% of patients at diagnosis. Most patients (93.1%) had positive staining for anaplastic lymphoma kinase. The five-year overall survival and event-free survival (EFS) rates were 79.7% and 73.3%, respectively. Bone marrow involvement, advanced stage, and thoracopulmonary ALCL were adverse prognostic factors for EFS (p=.05,.04, and.03, respectively). In multivariate analysis, only thoracopulmonary ALCL had a marginal significance on worse EFS (p=?.054). We suggested that children with thoracopulmonary ALCL may need to intensify the treatment, and introduction of new targeted therapies for relapsed/refractory disease will be required. ? 2019, ? 2019 Informa UK Limited, trading as Taylor & Francis Group. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060179179&doi=10.1080%2f10428194.2018.1562182&partnerID=40&md5=20d2fe8c47971fd5f8bc621cb6b45beb https://scholars.lib.ntu.edu.tw/handle/123456789/526392 |
ISSN: | 1042-8194 | DOI: | 10.1080/10428194.2018.1562182 | SDG/關鍵字: | anaplastic lymphoma kinase; antineoplastic agent; adult; allogeneic hematopoietic stem cell transplantation; anaplastic large cell lymphoma; Article; autologous hematopoietic stem cell transplantation; cancer diagnosis; cancer prognosis; cancer staging; child; childhood cancer; clinical feature; clinical outcome; cohort analysis; computer assisted tomography; drug megadose; event free survival; female; follow up; human; major clinical study; male; nuclear magnetic resonance imaging; overall survival; priority journal; Taiwan; treatment outcome; adolescent; age; anaplastic large cell lymphoma; health survey; mortality; outcome assessment; preschool child; prognosis; survival analysis; Adolescent; Age Factors; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Lymphoma, Large-Cell, Anaplastic; Male; Neoplasm Staging; Patient Outcome Assessment; Population Surveillance; Prognosis; Survival Analysis; Taiwan |
顯示於: | 醫學系 |
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