https://scholars.lib.ntu.edu.tw/handle/123456789/526434
標題: | Clinical features, prognostic factors, and their relationship with antiplatelet antibodies in children with immune thrombocytopenia | 作者: | Ho W.-L. Lee C.-C. Chen C.-J. MENG-YAO LU Hu F.-C. SHIANN-TANG JOU Lin D.-T. Lin K.-H. |
公開日期: | 2012 | 卷: | 34 | 期: | 1 | 起(迄)頁: | 6��12�� | 來源出版物: | Journal of Pediatric Hematology/Oncology | 摘要: | We investigated and evaluated the demographics, clinical and laboratory features, treatment responses, and disease duration of 25 children with immune thrombocytopenia (ITP) eligible for detection of antiplatelet antibodies. We found that patients without antecedent of preceding infection (API) were more likely to have anti-GPIa/IIa than those with API (42.9% vs. 5.5%, P=0.048). Age groups of <2 years and 2 to 10 years were more likely to show response (R) or complete response (CR) to given treatments, whereas none of the patients whose onset age >10 years showed R or CR to given treatments (88.9% and 100% vs 0%, P=0.001). The percentage of newly diagnosed ITP was higher in age groups of <2 years (100%) and in 2 to 10 years (90%) than the age group of >10 years (16.7%, P=0.001). Patients without API (71.4%) were more likely to develop chronic ITP than those with API (5.6%, P=0.002). In conclusion, younger age was a favorable prognostic factor, especially in patients <2 years of age with respect to treatment responses and disease duration. In addition, API was associated with a short disease course as well as absence of anti-GPIa/IIa. Copyright ? 2011 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855464680&doi=10.1097%2fMPH.0b013e3182282548&partnerID=40&md5=94bd7bb9c9b3d2d5aed596633128aea9 https://scholars.lib.ntu.edu.tw/handle/123456789/526434 |
ISSN: | 1077-4114 | DOI: | 10.1097/MPH.0b013e3182282548 | SDG/關鍵字: | CD36 antigen; fibrinogen receptor; HLA antigen; immunoglobulin; prednisolone; thrombin receptor; thrombocyte antibody; very late activation antigen 2; adolescent; antecedent of preceding infection; antibody detection; article; child; clinical article; clinical feature; controlled study; disease course; disease duration; disease severity; drug response; female; human; idiopathic thrombocytopenic purpura; infant; male; onset age; preschool child; priority journal; prognosis; school child; thrombocyte count; treatment outcome; vaccination; virus infection; Adolescent; Age Factors; Age of Onset; Autoantibodies; Blood Platelets; Child; Child, Preschool; Female; Humans; Infant; Male; Multivariate Analysis; Prognosis; Purpura, Thrombocytopenic, Idiopathic |
顯示於: | 醫學系 |
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