https://scholars.lib.ntu.edu.tw/handle/123456789/526450
標題: | Survival, mortality, and complications in patients with β-thalassemia major in northern Taiwan | 作者: | Chern J.P.S. Su S. Lin K.-H. SHU-HUI CHANG MENG-YAO LU SHIANN-TANG JOU Lin D.-T. Ho W.-L. Lin K.-S. |
公開日期: | 2007 | 卷: | 48 | 期: | 5 | 起(迄)頁: | 550-554 | 來源出版物: | Pediatric Blood and Cancer | 摘要: | Background. Advances in treatment have improved the prognosis in β-thalassemia major. We present the survival and complications pattern of those patients in northern Taiwan born after 1970. Procedure. One-hundred and sixty patients with β-thalassemia major born after 1970 were collected. The Kaplan-Meier method and log-rank test were used to estimate and compare survival. Cox regression models were used to examine the associations of bone marrow transplantation (BMT), time of BMT procedure, and time of complications with survival. Results. Better survival was observed for patients born after 1980 (P=0.0121). Heart disease, BMT-related deaths, and infections were the main causes of death. Among the living patients over age 15, hypogonadotropic hypogonadism, HCV infection, diabetes, heart failure, and arrhythmia were the common complications. No patients under age 15 had complications. Conclusions. Survival for patients with β-thalassemia major has improved significantly in Taiwan. More time is required to demonstrate whether these modalities added to the treatment of these patients will impact favorably on their outcome. Our success with BMT is improving and we are now in a position to offer this curative alternative. ? 2006 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947679901&doi=10.1002%2fpbc.21028&partnerID=40&md5=65a51e51b8bfa72a56b72472399dab4b https://scholars.lib.ntu.edu.tw/handle/123456789/526450 |
ISSN: | 1545-5009 | DOI: | 10.1002/pbc.21028 | SDG/關鍵字: | adolescent; adult; article; bone marrow transplantation; cause of death; child; diabetes mellitus; female; heart arrhythmia; heart disease; heart failure; hepatitis C; human; hypogonadotropic hypogonadism; infection; Kaplan Meier method; major clinical study; male; mortality; priority journal; prognosis; proportional hazards model; survival; Taiwan; thalassemia major; treatment outcome; Adolescent; Adult; Arrhythmia; beta-Thalassemia; Bone Marrow Transplantation; Cause of Death; Child; Child, Preschool; Diabetes Complications; Female; Heart Diseases; Heart Failure, Congestive; Hepatitis C; Humans; Hypogonadism; Infant; Infant, Newborn; Infection; Male; Prognosis; Survival Rate; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。