https://scholars.lib.ntu.edu.tw/handle/123456789/526494
Title: | Nephromegaly and elevated hepatocyte growth factor in children with biliary atresia | Authors: | YONG-KWEI TSAU Chen C.-H. MEI-HWEI CHANG Teng R.-J. MENG-YAO LU PING-ING LEE |
Issue Date: | 1997 | Publisher: | W.B. Saunders | Journal Volume: | 29 | Journal Issue: | 2 | Start page/Pages: | 188-192 | Source: | American Journal of Kidney Diseases | Abstract: | Nephromegaly, a rarely mentioned but probably common situation, was studied in children with biliary atresia. We evaluated the length and the cross-sectional diameters of the kidney by ultrasound in 21 children with biliary atresia as well as in 50 healthy children. The ages ranged from 1 month to 10 years. Plasma hepatocyte growth factor (HGF) was measured in 18 children with biliary atresia and also in 18 age- and sex-matched normal controls. There was a significant nephromegaly (increase in the renal length and the kidney volume) in children with biliary atresia as compared with normal children (P < 0.001 by analysis of covariance). Plasma HGF levels were elevated in these patients (2.13 ± 1.06 v 0.76 ± 0.19 ng/mL in controls, P < 0.001) and had a positive correlation with the renal size after considering the effect of body height by multiple regression analysis (P = 0.0022 for renal length, and P < 0.001 for kidney volume). These results confirm the presence of large kidneys in biliary atresia and implicate the possible pathogenic role of HGF in such a condition. Nephromegaly in biliary atresia may provide a new in vive model to study the mechanism of renal growth. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030983737&doi=10.1016%2fS0272-6386%2897%2990028-7&partnerID=40&md5=3b1a4c728bd756b8eb86786cfd5d5e53 https://scholars.lib.ntu.edu.tw/handle/123456789/526494 |
ISSN: | 0272-6386 | DOI: | 10.1016/S0272-6386(97)90028-7 | SDG/Keyword: | scatter factor; article; bile duct atresia; child; clinical article; controlled study; disease association; echography; female; human; infant; kidney disease; kidney size; male; statistical analysis [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
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