Adult sepsis – A nationwide study of trends and outcomes in a population of 23 million people
Journal
Journal of Infection
Journal Volume
75
Journal Issue
5
Pages
409-419
Date Issued
2017
Author(s)
Yo C.-H.
Lee M.-T.G.
Tsai K.-C.
Lee S.-H.
Chen Y.-S.
Lee W.-C.
Hsu T.-C.
Lee S.-H.
Chang S.-S.
Abstract
Objectives To determine the trend of incidence and outcome of sepsis based on a nationwide administrative database. Methods We analyzed the incidence and mortality of both emergency department treated and hospital treated sepsis from 2002 through 2012 using the entire health insurance claims data of Taiwan. The national health insurance covers 99% of residents in Taiwan. Sepsis patients were identified using a set of validated ICD-9CM codes conforming to the sepsis-3 definition. The 30-day all-cause mortality was verified by linked death certificate database. Results During the 11-year study period, a total of 1,259,578 episodes of sepsis was identified. The mean incidence rate was 639 per 100,000 person-years, increasing from 637.8/100,000 persons in 2002 to 772.1/100,000 persons in 2012 (annual increase: 1.9%). The mortality rate, however, has decreased from 27.8% in 2002 to 22.8% in 2012 (annual decrease: 0.45%). The trend of incidence and mortality did not change after standardization by age and gender using 2002 as the reference standard. Conclusion We showed that the incidence of sepsis has increased while the mortality has decreased in Taiwan. Despite the decreasing trend in sepsis mortality, the total number of sepsis mortality remains increasing due to the rapid increase in sepsis incidence. ? 2017 The British Infection Association
SDGs
Other Subjects
age; aged; Article; disease course; emergency ward; female; gender; hospital patient; human; ICD-9-CM; incidence; major clinical study; male; mortality rate; outcome assessment; population research; sepsis; Taiwan; trend study; cohort analysis; incidence; longitudinal study; mortality; sepsis; treatment outcome; Aged; Cohort Studies; Female; Humans; Incidence; Longitudinal Studies; Male; Sepsis; Taiwan; Treatment Outcome
Type
journal article