https://scholars.lib.ntu.edu.tw/handle/123456789/527364
標題: | Tourette syndrome as an independent risk factor for subsequent sleep disorders in children: A nationwide population-based case-control study | 作者: | WANG-TSO LEE Huang H.-L. LEE-CHIN WONG WEN-CHIN WENG Vasylenko T. Jong Y.-J. Lin W.-S. Ho S.-Y. |
公開日期: | 2017 | 出版社: | Associated Professional Sleep Societies,LLC | 卷: | 40 | 期: | 3 | 起(迄)頁: | zsw072 | 來源出版物: | Sleep | 摘要: | Study objectives: Tourette syndrome (TS) is associated with a variety of neuropsychiatric comorbidities. However, the relationship between TS and sleep disorders in children is less investigated. This nationwide population-based case-control study aimed to determine the correlation of TS and sleep disorders in children. Methods: Patients aged less than 18 years with newly diagnosed TS from 2001 to 2007 were collected (n = 1124) using data from Taiwan's National Health Insurance Research Database and were compared with a comparison cohort (n = 3372). The adjusted hazard ratio (aHR) for developing sleep disorders was calculated by multivariate Cox proportional hazards model. Results: TS was more prevalent in boys, with a male to female ratio of 3.16:1. TS group also had significantly higher urbanization level of residence than controls (p < .001). The overall incidence rate of sleep disorders was 7.24? in children with TS, compared to 3.53? in controls. The TS group was associated with a significantly higher rate of sleep disorders, with a crude HR of 2.05 (95% confidence inerval [CI] = 1.43-2.95, p < .001). Among the comorbidities of TS, anxiety disorder was associated with the highest risk for sleep disorders (crude HR = 3.26, 95% CI = 1.52-7.00, p < .001). The aHR for TS cohort to develop sleep disorders was 1.72 (95% CI = 1.16-2.53, p = .007). Conclusions: The increased risk of sleep disorders in children with TS cannot be fully attributed to its comorbidities, and TS is an independent risk factor for sleep disorders in children. ? 2017, Associated Professional Sleep Societies,LLC. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017155137&doi=10.1093%2fsleep%2fzsw072&partnerID=40&md5=6ee94e5587c58b0de4a00db40c33e4f1 https://scholars.lib.ntu.edu.tw/handle/123456789/527364 |
ISSN: | 0161-8105 | DOI: | 10.1093/sleep/zsw072 | SDG/關鍵字: | adolescent; allergic rhinitis; anxiety disorder; Article; atopic dermatitis; attention deficit disorder; child; childhood disease; cohort analysis; comorbidity; controlled study; depression; female; Gilles de la Tourette syndrome; human; incidence; infant; major clinical study; male; obesity; population based case control study; preschool child; priority journal; risk assessment; risk factor; school child; sleep disorder; urbanization; Anxiety Disorders; case control study; factual database; follow up; health survey; longitudinal study; prevalence; procedures; retrospective study; Sleep Wake Disorders; Taiwan; Tourette Syndrome; Adolescent; Anxiety Disorders; Case-Control Studies; Child; Child, Preschool; Comorbidity; Databases, Factual; Female; Follow-Up Studies; Humans; Infant; Longitudinal Studies; Male; Population Surveillance; Prevalence; Retrospective Studies; Risk Factors; Sleep Wake Disorders; Taiwan; Tourette Syndrome |
顯示於: | 醫學系 |
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