Benign convulsions with mild gastroenteritis: Is it associated with sodium channel gene SCN1A mutation?
Journal
Journal of Child Neurology
Journal Volume
25
Journal Issue
12
Pages
1521-1524
Date Issued
2010
Author(s)
Abstract
Benign convulsions with mild gastroenteritis were afebrile seizures associated with gastroenteritis in previously healthy infants or young children. It has been thought to be a continual spectrum of benign infantile convulsions because of overlapping clinical pictures. Recently, molecular genetic studies have suggested a channelopathy in benign infantile convulsions. The authors prospectively studied the clinical features of benign convulsions with mild gastroenteritis in Taiwanese children and clarified the relationship between neuronal sodium channel alpha 1 subunit (SCN1A) gene and benign convulsions with mild gastroenteritis. The clinical pictures in their patients were similar to those of previous studies except for the low rate of positive rotavirus antigen in the stool, which may indicate a season-related viral infection. No mutations in the SCN1A gene were identified in all patients. This study suggested that SCN1A mutations are probably not associated with benign convulsions with mild gastroenteritis. Other possible pathogenic mechanisms need to be researched in the future. ? 2010 The Author(s).
SDGs
Other Subjects
antigen; sodium channel Nav1.1; article; benign childhood epilepsy; child; clinical article; clinical feature; clinical trial; disease severity; feces analysis; female; gastroenteritis; gene mutation; human; male; preschool child; priority journal; Rotavirus; Taiwan; Asian Continental Ancestry Group; Epilepsy, Benign Neonatal; Female; Gastroenteritis; Genetic Markers; Genetic Predisposition to Disease; Humans; Infant; Male; Nerve Tissue Proteins; Prospective Studies; Sodium Channels; Taiwan
Type
journal article