https://scholars.lib.ntu.edu.tw/handle/123456789/527423
標題: | The correlation between neurological evaluations and neurological outcome in acute encephalitis: A hospital-based study | 作者: | Wang I.-J. PING-ING LEE LI-MIN HUANG Chen C.-J. CHI-LING CHEN WANG-TSO LEE |
公開日期: | 2007 | 卷: | 11 | 期: | 2 | 起(迄)頁: | 63-69 | 來源出版物: | European Journal of Paediatric Neurology | 摘要: | Acute encephalitis is a common CNS infectious disease in children. However, there are limited studies concerning about the correlation between the clinical evaluations and neurological outcome. To investigate the value of neurological evaluations, and the correlation between these evaluations and neurological outcomes of acute encephalitis, in the present study we retrospectively evaluated the neurological outcome of 0- to 16-year-old children with encephalitis or meningoencephalitis between 1999 and 2000. Of 101 children enrolled, 4 died and 25 had other neurological sequelae, including epilepsy, headache, developmental delay, and emotional or behavioral changes during the 5 years of follow-up. The causative organisms in patients with neurological sequelae were herpes virus (HSV) 2/2 (100%), influenza 2/3 (67%), mycoplasma 5/12 (42%), and enterovirus 71 2/7 (29%). The important predictors for adverse outcomes were focal neurological signs, multiple seizures or status epilepticus on admission, leukopenia, focal slow waves or continuous generalized delta waves in electroencephalography (EEG), and focal cortical parenchymal hyperintensity in the magnetic resonance imaging (MRI) (p<0.05). Patients with initial presentations of focal neurological signs, papilledema, myoclonic jerks, and status epilepticus tended to have higher incidence of abnormal findings in brain MRI, although not achieving statistic significances. In addition, children with focal spikes or continuous generalized delta waves in EEG also had higher incidence of MRI abnormalities. We conclude that brain MRI studies may be indicated in patients with focal neurological signs, intractable seizure, and focal spikes, focal delta waves, or continuous generalized delta waves in EEG. For those with MRI examinations, focal cortical hyperintensity suggests poorer neurological outcomes. ? 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847216120&doi=10.1016%2fj.ejpn.2006.09.010&partnerID=40&md5=3d2f675ed5181d1eed3eaf55b48b52cc https://scholars.lib.ntu.edu.tw/handle/123456789/527423 |
ISSN: | 1090-3798 | DOI: | 10.1016/j.ejpn.2006.09.010 | SDG/關鍵字: | aciclovir; immunoglobulin; phenobarbital; Adenovirus; adolescent; article; behavior disorder; central nervous system infection; cerebrospinal fluid analysis; child; child death; clinical evaluation; correlation analysis; Cytomegalovirus; delta rhythm; developmental disorder; electroencephalography; emotional disorder; encephalitis; Enterovirus; epilepsy; epileptic state; Epstein Barr virus; fever; follow up; headache; Herpes simplex virus; Herpes virus; hospital admission; human; Human herpesvirus 6; incidence; infant; Influenza virus; Japanese encephalitis virus; leukopenia; meningoencephalitis; Mycoplasma; myoclonus seizure; neurologic examination; nuclear magnetic resonance imaging; outcome assessment; papilledema; prediction; priority journal; Rotavirus; serology; slow brain wave; statistical significance; symptom; virus isolation; Acute Disease; Adolescent; Child; Child, Preschool; Encephalitis; Female; Follow-Up Studies; Hospitals; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Neurologic Examination; Odds Ratio; Predictive Value of Tests; Retrospective Studies; Treatment Outcome |
顯示於: | 醫學系 |
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