https://scholars.lib.ntu.edu.tw/handle/123456789/528118
標題: | Lemierre's syndrome: A forgotten and re-emerging infection | 作者: | Lee W.-S. Jean S.-S. Chen F.-L. SZU-MIN HSIEH PO-REN HSUEH |
公開日期: | 2020 | 卷: | 53 | 期: | 4 | 起(迄)頁: | 513-517 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Lemierre's syndrome, also known as post-anginal septicemia or necrobacillosis, is characterized by bacteremia, internal jugular vein thrombophlebitis, and metastatic septic emboli secondary to acute pharyngeal infections. Modern physicians have “forgotten” this disease. The most common causative agent of Lemierre's syndrome is Fusobacterium necrophorum, followed by Fusobacterium nucleatum and anaerobic bacteria such as streptococci, staphylococci, and Klebsiella pneumoniae. The causative focus mostly originated from pharyngitis or tonsillitis, accounting for over 85% of the cases of Lemierre's syndrome. Pneumonia or pleural empyema is the most common metastatic infection in Lemierre's syndrome. Antimicrobial therapy should be prescribed for 3–6 weeks. The treatment regimens include metronidazole and β-lactam antibiotics. In recent years, the antibiotic stewardship program has resulted in decreased antibiotic prescription for upper respiratory tract infections. The incidence of Lemierre's syndrome has increased over the past decade. F. necrophorum is an underestimated cause of acute pharyngitis or tonsillitis. A high index of suspicion is required for the differential diagnosis of acute tonsillopharyngitis with persistent neck pain and septic syndrome. ? 2020 |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528118 | ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2020.03.027 | SDG/關鍵字: | beta lactam antibiotic; metronidazole; antiinfective agent; antibiotic therapy; antimicrobial stewardship; clinical feature; Fusobacterium necrophorum; Fusobacterium nucleatum; human; Klebsiella pneumoniae; Lemierre syndrome; nonhuman; pathogenesis; pleura empyema; pneumonia; Review; Staphylococcus; Streptococcus; anaerobic bacterium; bacterium; classification; communicable disease; Lemierre syndrome; microbiology; pathogenicity; pharyngitis; sepsis; Anti-Bacterial Agents; Bacteria; Bacteria, Anaerobic; Communicable Diseases, Emerging; Fusobacterium necrophorum; Humans; Lemierre Syndrome; Pharyngitis; Sepsis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。