https://scholars.lib.ntu.edu.tw/handle/123456789/528347
標題: | Community-acquired pneumonia and tuberculosis: DIFFERENTIAL diagnosis and the use of fluoroquinolones | 作者: | Grossman R.F. PO-REN HSUEH Gillespie S.H. Blasi F. |
公開日期: | 2014 | 卷: | 18 | 期: | 1 | 起(迄)頁: | 14-21 | 來源出版物: | International Journal of Infectious Diseases | 摘要: | The respiratory fluoroquinolones moxifloxacin, gemifloxacin, and high-dose levofloxacin are recommended in guidelines for effective empirical antimicrobial therapy of community-acquired pneumonia (CAP). The use of these antibiotics for this indication in areas with a high prevalence of tuberculosis (TB) has been questioned due to the perception that they contribute both to delays in the diagnosis of pulmonary TB and to the emergence of fluoroquinolone-resistant strains of Mycobacterium tuberculosis. In this review, we consider some of the important questions regarding the potential use of fluoroquinolones for the treatment of CAP where the burden of TB is high. The evidence suggests that the use of fluoroquinolones as recommended for 5-10 days as empirical treatment for CAP, according to current clinical management guidelines, is appropriate even in TB-endemic regions. It is critical to quickly exclude M. tuberculosis as a cause of CAP using the most rapid relevant diagnostic investigations in the management of all patients with CAP. ? 2013 The Authors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528347 | ISSN: | 1201-9712 | DOI: | 10.1016/j.ijid.2013.09.013 | SDG/關鍵字: | clarithromycin; ethambutol; gatifloxacin; isoniazid; levofloxacin; moxifloxacin; ofloxacin; pyrazinamide; quinolone derivative; rifampicin; rifapentine; antibacterial activity; antibiotic resistance; antibiotic therapy; community acquired pneumonia; differential diagnosis; drug use; human; lung tuberculosis; monotherapy; review; thorax radiography; tuberculin test; tuberculosis; Differential diagnosis; Fluoroquinolone; Mycobacterium tuberculosis; Pneumonia; Resistance; Tuberculosis; Anti-Bacterial Agents; Community-Acquired Infections; Diagnosis, Differential; Dose-Response Relationship, Drug; Fluoroquinolones; Humans; Mycobacterium tuberculosis; Pneumonia; Prevalence; Tuberculosis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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