Risk factors and pathogenic significance of bacteremic pneumonia in adult patients with community-acquired pneumococcal pneumonia
Journal
Journal of Infection
Journal Volume
66
Journal Issue
1
Pages
34-40
Date Issued
2013
Author(s)
Kang C.-I.
Song J.-H.
Kim S.H.
Chung D.R.
Peck K.R.
Thamlikitkul V.
Wang H.
So T.M.K.
Yasin R.M.
Carlos C.C.
Van P.H.
Perera J.
Abstract
Objective: This study was performed to identify risk factors for the development of bacteremic pneumonia and to evaluate the impact of bacteremia on the outcome of pneumococcal pneumonia. Methods: Using a database from a surveillance study of community-acquired pneumococcal pneumonia, we compared data of the bacteremic group with that of the non-bacteremic group. Results: Among 981 adult patients with pneumococcal pneumonia, 114 (11.6%) patients who had documented pneumococcal bacteremia were classified into the bacteremic group. In a multivariable analysis, use of immunosuppressant drugs, younger age (<65 years), and DM were independent risk factors associated with the development of bacteremic pneumonia among patients with pneumococcal pneumonia (all P < 0.05). The mortality rate was significantly higher in the bacteremic group than in the non-bacteremic group (28.6% vs. 8.5%; P < 0.001). The multivariable analysis revealed that concomitant bacteremia was one of the significant risk factors associated with mortality (OR, 2.57; 95% CI, 1.24-5.29), along with cerebrovascular disease and presentation with septic shock (all P < 0.05). Conclusions: Bacteremia was a common finding in pneumococcal pneumonia and was associated with a higher mortality rate. Several clinical variables may be useful for predicting bacteremic pneumonia among patients with pneumococcal pneumonia. ? 2012.
SDGs
Other Subjects
immunosuppressive agent; adult; age; aged; article; bacteremia; bacterial pneumonia; cerebrovascular disease; community acquired pneumonia; controlled study; diabetes mellitus; female; human; major clinical study; male; mortality; prognosis; risk factor; septic shock; smoking; Streptococcus pneumonia; Streptococcus pneumoniae; Aged; Asia; Bacteremia; Chi-Square Distribution; Community-Acquired Infections; Female; Humans; Male; Middle Aged; Multivariate Analysis; Pneumonia, Pneumococcal; Prospective Studies; Risk Factors; Streptococcus pneumoniae
Type
journal article