https://scholars.lib.ntu.edu.tw/handle/123456789/528447
標題: | Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006-2007 | 作者: | Li C.-F. Liu M.-F. Shi Z.-Y. PO-REN HSUEH Liao C.-H. Jang T.-N. Tsao S.-M. HSIANG-CHI KUNG Hsu G.-J. Cheng Y.-J. Lin H.-C. Liu Y.-C. Chuang Y.-C. Wang L.-S. Chen C.-M. |
公開日期: | 2012 | 卷: | 45 | 期: | 4 | 起(迄)頁: | 305-310 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background: Multiple antibiotic-resistant clones of Streptococcus pneumoniae have spread throughout the world and continue to evolve under the selective pressure of antibiotics and vaccines. The aim of this study is to assess the susceptibility of S. pneumoniae isolates and to analyze the resistance trends in Taiwan. Methods: Antimicrobial susceptibility tests were performed on 152 nonmeningeal isolates of S. pneumoniae that were collected from 13 different hospitals around Taiwan from 2006-2007. Tests were performed using the broth microdilution method according to recommendations of the Clinical and Laboratory Standards Institute. Results: The minimal inhibitory concentrations (MIC50/MIC90) of penicillin, cefotaxime, vancomycin, and moxifloxacin were 0.5/1.0, 0.25/1.0, 0.25/0.5, and 0.06/0.12 μg/mL, respectively. The susceptibility rates of penicillin, cefotaxime, vancomycin, and moxifloxacin were 99.3%, 99.3%, 100%, and 98.7%, respectively. However, if the meningitis breakpoints were applied to these nonmeningeal isolates, the susceptibility rates of penicillin and cefotaxime were reduced to 18.4% and 76.3%, respectively. Compared with the findings from previous studies in Taiwan, our results show that the percentage of S. pneumoniae isolates with a penicillin MIC of 0.12-1.0 μg/mL increased from 43.3% in 1996-1997 to 73.7% in 2006-2007 (p < 0.001). The percentage of S. pneumoniae isolates with a cefotaxime MIC of 1.0 μg/mL increased from 11.3% in 1996-1997 to 23.0% in 2006-2007 (p < 0.001). Regarding the serial MIC intervals of the four antimicrobial agents, there was no significant difference between bacteremic and nonbacteremic isolates. Conclusion: Although nonmeningeal S. pneumoniae isolates remained susceptible to penicillin, the proportion of isolates with a penicillin MIC of 0.12-1.0 μg/mL or cefotaxime MIC of 1.0 μg/mL increased during the past decade in Taiwan. The ever-increasing resistance of S. pneumoniae has a great impact on the treatment of meningitis. ? 2012. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528447 | ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2011.12.012 | SDG/關鍵字: | cefotaxime; moxifloxacin; penicillin G; vancomycin; antibiotic resistance; antibiotic sensitivity; article; bacteremia; bacterial meningitis; bacterial strain; bacterium culture; bacterium isolate; broth dilution; colony forming unit; cross resistance; laboratory test; minimum inhibitory concentration; nonhuman; pleura fluid; pus; sputum analysis; Streptococcus pneumoniae; Taiwan; trend study; university hospital; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Cefotaxime; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Penicillins; Quinolines; Streptococcus pneumoniae; Taiwan; Vancomycin |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。