https://scholars.lib.ntu.edu.tw/handle/123456789/528479
標題: | Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study | 作者: | Kim S.H. Song J.-H. Chung D.R. Thamlikitkul V. Yang Y. Wang H. Lu M. So T.M.-K. PO-REN HSUEH Yasin R.M. Carlos C.C. Van Pham H. Lalitha M.K. Shimono N. Perera J. Shibl A.M. Baek J.Y. Kang C.-I. Ko K.S. Peck K.R. |
公開日期: | 2012 | 卷: | 56 | 期: | 3 | 起(迄)頁: | 1418-1426 | 來源出版物: | Antimicrobial Agents and Chemotherapy | 摘要: | Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin- nonsusceptible pneumococci (MIC,?4 μg/ml) was 4.6% and penicillin resistance (MIC,?8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A. Copyright ? 2012, American Society for Microbiology. All Rights Reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/528479 | ISSN: | 0066-4804 | DOI: | 10.1128/AAC.05658-11 | SDG/關鍵字: | amoxicillin; amoxicillin plus clavulanic acid; antibiotic agent; azithromycin; bacterial protein; ceftriaxone; cefuroxime; ciprofloxacin; clarithromycin; clindamycin; cotrimoxazole; ermB protein; erythromycin; gatifloxacin; levofloxacin; macrolide; mefA protein; moxifloxacin; penicillin G; unclassified drug; antibiotic resistance; article; Asian; bacterium isolate; China; Hong Kong; human; in vitro study; India; Malaysia; minimum inhibitory concentration; nonhuman; Philippines; priority journal; prospective study; South Korea; Sri Lanka; Streptococcus pneumoniae; Taiwan; Viet Nam; Anti-Bacterial Agents; Asia; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Penicillin Resistance; Pneumococcal Infections; Pneumococcal Vaccines; Prospective Studies; Serotyping; Streptococcus pneumoniae; Vaccination |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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