Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: Report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009-2010
Journal
International Journal of Antimicrobial Agents
Journal Volume
38
Journal Issue
5
Pages
376-383
Date Issued
2011
Author(s)
Wang H.
Chen M.
Xu Y.
Sun H.
Yang Q.
Hu Y.
Cao B.
Chu Y.
Liu Y.
Zhang R.
Yu Y.
Sun Z.
Zhuo C.
Ni Y.
Hu B.
Tan T.Y.
Wang J.-H.
Ko W.-C.
Chen Y.-H.
Wahjono H.
Abstract
A multicentre resistance surveillance study [Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS)] investigating the susceptibilities of 2963 clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, meticillin-susceptible Staphylococcus aureus (MSSA) and Streptococcus spp. from Asia against 12 antimicrobial agents was undertaken from 2009 to 2010. Based on the breakpoints for oral penicillin V recommended by the Clinical and Laboratory Standards Institute, the prevalence of penicillin-non-susceptible S. pneumoniae (PNSSP) ranged from 46% to 100%. Azithromycin and clarithromycin exhibited variable resistance rates of 0-88% against S. pneumoniae, 0-57% against MSSA and 0-76.5% against Streptococcus spp. isolates. The prevalence of extended-spectrum β-lactamase-producing K. pneumoniae varied from 5.1% to 58.5%. β-Lactamase production rates amongst H. influenzae isolates ranged from 15% to 46.6% and amongst M. catarrhalis isolates from 90% to 100%. Amongst M. catarrhalis isolates, macrolide resistance and cefaclor resistance rates of 5.8% and 1.2%, respectively, were found, mainly in Mainland China. Levofloxacin resistance rates of 0-3.9% with a MIC 90 (minimum inhibitory concentration causing inhibition of 90% of isolates) of 1-2 mg/L and moxifloxacin resistance rates of 0-1.7% with a MIC 90 of 0.125-0.5 mg/L were found amongst PNSSP isolates. Moxifloxacin was very active against Streptococcus spp., H. influenzae and M. catarrhalis isolates, with MIC 90 values of 0.125-0.25, 0.032-0.5 and 0.064-0.125 mg/L, respectively. These results from the CARTIPS study have confirmed some significant regional differences in the antimicrobial susceptibilities of S. pneumoniae, MSSA, K. pneumoniae, H. influenzae and Streptococcus spp. and emphasise the importance of antimicrobial surveillance programmes for guiding empirical therapy and for focusing interventional control of antimicrobial resistance in distinct geographic areas. ? 2011 Elsevier B.V. and the International Society of Chemotherapy.
SDGs
Other Subjects
amoxicillin plus clavulanic acid; azithromycin; beta lactamase; cefaclor; ceftazidime; ceftriaxone; cefuroxime; clarithromycin; levofloxacin; macrolide; moxifloxacin; penicillin G; penicillin V; antibiotic resistance; antibiotic sensitivity; article; Asia; bacterial infection; bacterium isolate; China; communicable disease; controlled study; disease surveillance; extended spectrum beta lactamase producing Enterobacteriaceae; Haemophilus influenzae; Klebsiella pneumoniae; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; Moraxella catarrhalis; nonhuman; penicillin resistance; prevalence; priority journal; respiratory tract infection; strain difference; Streptococcus; Streptococcus pneumoniae; Anti-Bacterial Agents; Asia; Community-Acquired Infections; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Population Surveillance; Respiratory Tract Infections
Type
journal article