|Title:||Characteristics of skin and soft tissue infection caused by non-tuberculous mycobacteria in Taiwan||Authors:||Hsiao C.-H.
|Issue Date:||2011||Journal Volume:||15||Journal Issue:||6||Start page/Pages:||811-817+i||Source:||International Journal of Tuberculosis and Lung Disease||Abstract:||
SETTING: A medical centre in Taipei, Taiwan. OBJECTIVE: To investigate the clinicopathological and microbiological correlates of skin and soft tissue infection (SSTI) due to non-tuberculous mycobacteria (NTM). DESIGN: Patients with NTM SSTI identified from 1999 to 2009 were included. Histological sections of the skin biopsy specimens from these patients were reassessed. RESULTS: Among 58 patients with NTM SSTI, the most commonly isolated NTM were rapidly growing mycobacteria (RGM; n = 30), Mycobacterium marinum (n = 17) and M. avium complex (MAC) (n = 4). Twentynine (50%) of the NTM SSTI involved deep soft tissue; these progressed to local tenosynovitis in 20 patients. All of the cutaneous lesions infected with M. marinum occurred on the upper extremities; in 9 patients the skin eruptions developed after injury in an aquatic environment. Skin lesions with RGM infection usually occurred on the lower extremities, and in 6 patients the infection developed from wounds caused by medical procedures. Granulomatous inflammation with fibrinoid necrosis was present in 47% of lesions in patients with M. marinum infection and suppurative granulomatous inflammation was noted in 45% of patients with RGM infection. CONCLUSIONS: Identification of a close clinicopathological correlate is useful for dermatologists and pathologists in the early diagnosis and treatment of NTM SSTI. ? 2011 The Union.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/528522||ISSN:||1027-3719||DOI:||10.5588/ijtld.10.0481||SDG/Keyword:||ciprofloxacin; clarithromycin; ethambutol; minocycline; rifampicin; adult; article; atypical mycobacteriosis; bacterium identification; bacterium isolate; combination chemotherapy; controlled study; early diagnosis; female; granulomatous inflammation; histopathology; human; human tissue; major clinical study; male; Mycobacterium; Mycobacterium arupense; Mycobacterium chelonei; Mycobacterium fortuitum; Mycobacterium gordonae; Mycobacterium haemophilum; Mycobacterium intracellulare avium; Mycobacterium kansasii; Mycobacterium marinum; nonhuman; priority journal; rash; skin biopsy; skin infection; soft tissue infection; Taiwan; tenosynovitis; treatment duration; Adolescent; Adult; Aged; Antitubercular Agents; Child; Female; Humans; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Risk Factors; Skin Diseases, Bacterial; Soft Tissue Infections; Taiwan; Treatment Outcome; Young Adult
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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