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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/528584
Title: Clinicopathologic characteristics of nontuberculous mycobacterial lung disease in Taiwan
Authors: Hsiao C.-H.
Lin Y.-T.
Lai C.-C.
PO-REN HSUEH 
Issue Date: 2010
Journal Volume: 68
Journal Issue: 3
Start page/Pages: 228-235
Source: Diagnostic Microbiology and Infectious Disease
Abstract: 
Taiwan is an endemic area for tuberculosis (TB), and the incidence of pulmonary infection caused by nontuberculous mycobacteria (NTMs) is also increasing. This study aims to investigate the clinicopathologic characteristics of patients with NTM lung disease during 1998 to 2007 at a medical center in Taiwan. The medical records of patients with confirmed NTM pulmonary infections who underwent open lung surgery in a medical center were reviewed. Twenty-four patients with confirmed NTM pulmonary infections were identified. These patients were histologically classified into 4 types: fibrocavitary/tuberculoid (n = 10), nodular bronchiectatic (n = 4), sarcoidal (n = 6), and other (n = 4). The fibrocavitary/tuberculoid type usually (90%) develops in the upper lobes of old patients with preexisting lung disease. Pulmonary TB (n = 7, 70%) was the major underlying disease before 2003. Nodular bronchiectatic type occurred mainly in the middle lobe of middle-aged women without preexisting lung disease. Sarcoidal type was usually associated with Mycobacterium avium complex infection and develops in middle-aged women. Immunoreactive bacilli were detected in 21 patients (87 %) by immunohistochemical staining using a polyclonal antibody against Mycobacterium tuberculosis and other mycobacterial species (M. avium-intracellulare, Mycobacterium phlei, and Mycobacterium parafortuitum), whereas conventional acid-fast staining was positive in only 21% of patients. In conclusion, TB was the major underlying disease in patients with NTM lung disease in Taiwan. The different histologic types of pulmonary NTM infection suggest each had a distinct pathogenesis. ? 2010 Elsevier Inc.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/528584
ISSN: 0732-8893
DOI: 10.1016/j.diagmicrobio.2010.06.008
SDG/Keyword: acid fast bacterium; adult; aged; article; atypical mycobacteriosis; bacterium detection; bronchiectasis; clinical article; controlled study; disease classification; female; human; immunohistochemistry; lung cavitation; lung infection; lung lobe; lung sarcoidosis; lung surgery; male; medical record review; middle aged; multiple pulmonary nodules; Mycobacterium; Mycobacterium avium; Mycobacterium intracellulare avium; mycobacterium parafortuitum; Mycobacterium phlei; Mycobacterium tuberculosis; nontuberculous mycobacteriosis; pathogenesis; priority journal; species comparison; Taiwan; trend study; tuberculosis; Academic Medical Centers; Adult; Aged; Female; Humans; Immunohistochemistry; Lung; Lung Diseases; Male; Microscopy; Middle Aged; Mycobacterium; Mycobacterium Infections, Atypical; Taiwan
[SDGs]SDG3
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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