https://scholars.lib.ntu.edu.tw/handle/123456789/529250
標題: | Incidence and postnatal profile of fontan patients by adolescence from a nationwide birth cohort | 作者: | Lee M.-C. MEI-HWAN WU MING-TAI LIN Chen H.-C. Kao F.-Y. Huang S.-K. |
公開日期: | 2020 | 出版社: | Republic of China Society of Cardiology | 卷: | 36 | 期: | 4 | 起(迄)頁: | 367-374 | 來源出版物: | Acta Cardiologica Sinica | 摘要: | Background: Although the Fontan procedure is associated with a variety of long-term complications, it is the mainstay treatment for congenital heart disease with a functioning single ventricle. Data concerning the epidemiological profile are scarce. Methods: We investigated the current epidemiological profile using a 2000-2008 nationwide birth cohort from a 2000-2014 database (1,967,991 live births), with complete postnatal data for at least 6 years. We identified 363 patients (2792 patient-years of follow-up) who had received the Fontan procedure, giving an incidence of 0.184/ 1000 live births. Results: The overall Fontan surgical survival rate was 81.8%. In post-Fontan patients, the 10-year survival was 0.822 (±0.026). Causes of death included cardiac (43.8%), infection (20.8%), out-of-hospital death (16.7%), sudden death (8.3%), cerebral vascular accident (8.3%) and malignancy (2.1%). The risk of unexpected death (sudden death and out-of-hospital death) was 4.0%, or 0.55% per post-Fontan patient-year. Arrhythmias were common (12.1%). Supraventricular tachycardia was the most common type of arrhythmia, and occurred prior to the Fontan procedure in 22 patients, with a cumulative risk of 2.2%, 6.3%, and 11.6% by the age of 1, 5 and 10 years, respectively. Arrhythmia intervention was performed in 40.9% of those with arrhythmia, including electrophysiological studies/ ablation in 12 and device therapy in 6 patients. Conclusions: In conclusion, the incidence of Fontan patients was 0.184/1000 live births. Their medical complexity included a high risk of supraventricular tachycardia and unexpected death by adolescence. ? 2020, Republic of China Society of Cardiology. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087826323&doi=10.6515%2fACS.202007_36%284%29.20200207B&partnerID=40&md5=a5b8f32fb78b49bcb9e2e2641aa7a1df https://scholars.lib.ntu.edu.tw/handle/123456789/529250 |
ISSN: | 1011-6842 | DOI: | 10.6515/ACS.202007_36(4).20200207B | SDG/關鍵字: | adolescent; Article; bradycardia; brain abscess; cardiovascular mortality; cerebrovascular accident; child; cohort analysis; congenital heart disease; congenitally corrected transposition of the great arteries; Ebstein anomaly; electrophysiology; endocardial cushion defect; endocarditis; female; Fontan procedure; heart arrhythmia; heart right ventricle double outlet; heterotaxy syndrome; human; isomerism; lung vein drainage anomaly; major clinical study; male; out of hospital cardiac arrest; perinatal period; preschool child; pulmonary valve atresia; pulmonary valve stenosis; radiofrequency ablation; school child; sepsis; sudden death; supraventricular tachycardia; tachycardia; tricuspid valve atresia |
顯示於: | 醫學系 |
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