https://scholars.lib.ntu.edu.tw/handle/123456789/529704
標題: | Methimazole-induced lupus erythematosus: A case report | 作者: | LI-CHIEH WANG WEN-YU TSAI YAO-HSU YANG BOR-LUEN CHIANG |
公開日期: | 2003 | 卷: | 36 | 期: | 4 | 起(迄)頁: | 278-281 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | A 15-year-old girl had a history of diffuse goiter and received methimazole treatment 2 months before admission to the hospital. She developed bilateral lower leg edema 5 days before admission and the laboratory examinations revealed leukopenia, anemia, proteinuria, and granular cast. Positive antinuclear antibodies and anti-double strand (anti-ds) DNA antibodies were noted, although complement levels were not reduced, Myeloperoxidase antineutrophil cytoplasmic antibody was positive, A renal biopsy disclosed that there was focal segmental glomerulosclerosis. Methimazole was discontinued, and she was treated with prednisolone and Plaquenil, after which the symptoms and laboratory tests became normal within 40 days. The prednisolone was discontinued after treatment for seven months. Currently, the anti-dsDNA, C3, C4, CBC, urinalysis, and thyroid function tests are within normal limits. With hydroxychloroquine and levothyroxine, she was free of symptoms after discontinuation of methimazole until new (about 21 months). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0346394264&partnerID=40&md5=be2ad75aa176430e0223b251a12ffd25 https://scholars.lib.ntu.edu.tw/handle/123456789/529704 |
ISSN: | 0253-2662 | SDG/關鍵字: | antinuclear antibody; complement component C3; complement component C4; DNA antibody; double stranded DNA; hydroxychloroquine; levothyroxine; myeloperoxidase; neutrophil cytoplasmic antibody; prednisolone; thiamazole; adolescent; anemia; antibody detection; article; blood cell count; case report; clinical feature; disease course; drug induced disease; female; focal glomerulosclerosis; goiter; hospital admission; human; human tissue; kidney biopsy; laboratory test; leg edema; leukopenia; lower leg; lupus erythematosus; proteinuria; symptom; thyroid function test; treatment outcome; urinalysis; Adolescent; Antibodies; Antibodies, Antinuclear; DNA; Female; Glucocorticoids; Goiter; Humans; Hydroxychloroquine; Lupus Nephritis; Methimazole; Prednisolone; Thyroxine |
顯示於: | 醫學系 |
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