Methimazole-induced lupus erythematosus: A case report
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
36
Journal Issue
4
Pages
278-281
Date Issued
2003
Author(s)
Abstract
A 15-year-old girl had a history of diffuse goiter and received methimazole treatment 2 months before admission to the hospital. She developed bilateral lower leg edema 5 days before admission and the laboratory examinations revealed leukopenia, anemia, proteinuria, and granular cast. Positive antinuclear antibodies and anti-double strand (anti-ds) DNA antibodies were noted, although complement levels were not reduced, Myeloperoxidase antineutrophil cytoplasmic antibody was positive, A renal biopsy disclosed that there was focal segmental glomerulosclerosis. Methimazole was discontinued, and she was treated with prednisolone and Plaquenil, after which the symptoms and laboratory tests became normal within 40 days. The prednisolone was discontinued after treatment for seven months. Currently, the anti-dsDNA, C3, C4, CBC, urinalysis, and thyroid function tests are within normal limits. With hydroxychloroquine and levothyroxine, she was free of symptoms after discontinuation of methimazole until new (about 21 months).
SDGs
Other Subjects
antinuclear antibody; complement component C3; complement component C4; DNA antibody; double stranded DNA; hydroxychloroquine; levothyroxine; myeloperoxidase; neutrophil cytoplasmic antibody; prednisolone; thiamazole; adolescent; anemia; antibody detection; article; blood cell count; case report; clinical feature; disease course; drug induced disease; female; focal glomerulosclerosis; goiter; hospital admission; human; human tissue; kidney biopsy; laboratory test; leg edema; leukopenia; lower leg; lupus erythematosus; proteinuria; symptom; thyroid function test; treatment outcome; urinalysis; Adolescent; Antibodies; Antibodies, Antinuclear; DNA; Female; Glucocorticoids; Goiter; Humans; Hydroxychloroquine; Lupus Nephritis; Methimazole; Prednisolone; Thyroxine
Type
journal article