https://scholars.lib.ntu.edu.tw/handle/123456789/530098
標題: | Universal hepatitis B vaccination reduces childhood hepatitis B virus - Associated membranous nephropathy | 作者: | Liao M.-T. MEI-HWEI CHANG Lin F.-G. I-JUNG TSAI Chang Y.-W. Tsau Y.-K. |
公開日期: | 2011 | 卷: | 128 | 期: | 3 | 起(迄)頁: | e600-e604 | 來源出版物: | Pediatrics | 摘要: | OBJECTIVE: To compare the incidence of hepatitis B virus (HBV)-associated membranous nephropathy (HBVMN) before and after universal HBV vaccination and to identify factors underlying the change. METHODS: This study included 471 hospitalized children with nephrotic syndrome (NS) and 488 long-term follow-up hepatitis B surface antigen (HBsAg)-carrier children. Horizontal transmission (negative maternal HBsAg status) of HBVMN and HBV was assessed, and the incidence of HBVMN was compared before and after initiation of the universal HBV vaccination program started in 1984. RESULTS: The frequency of HBVMN in children with NS was 11.6% between 1974 and 1984, 4.5% between 1984 and 1994, 2.1% between 1994 and 2004, and 0% between 2004 and 2009. Similarly, the number of HBsAg-seropositive children with NS (mainly via horizontal infection) decreased after universal vaccination. The prevaccination frequency of HBV horizontal transmission in chronic HBsAg carriers from the general population was 36.5% compared with 5% in the postvaccination period. The incidence of HBVMN in these carriers revealed a parallel decline. CONCLUSIONS: Our results revealed a significant decrease in the frequency of HBVMN in children with NS and in long-term follow-up HBsAg carriers. Children with HBVMN are primarily infected with HBV via horizontal transmission; thus, the significant reduction in horizontal transmission in HBsAg-carrier children in the general population after universal HBV vaccination may explain the reduction of HBVMN in the vaccinated population. These findings confirm the effectiveness of HBV vaccination on reducing the incidence of HBVMN, possibly through a significant decline in horizontal HBV infection. Copyright ? 2011 by the American Academy of Pediatrics. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052387827&doi=10.1542%2fpeds.2010-3137&partnerID=40&md5=dcd1b51ff6bf4c5a60529bebd796f6e7 https://scholars.lib.ntu.edu.tw/handle/123456789/530098 |
ISSN: | 0031-4005 | DOI: | 10.1542/peds.2010-3137 | SDG/關鍵字: | h b vax ii; hepatitis B surface antigen; hepatitis B vaccine; life guard; recombinant hepatitis B vaccine; unclassified drug; article; child; child hospitalization; comparative study; controlled study; disease transmission; female; follow up; health program; hepatitis B; hepatitis B virus associated membranous nephropathy; horizontal transmission; human; incidence; long term care; major clinical study; male; membranous glomerulonephritis; nephrotic syndrome; priority journal; school child; vaccination; Child; Disease Transmission, Infectious; Female; Glomerulonephritis, Membranous; Hepatitis B; Hepatitis B Vaccines; Humans; Male; Nephrotic Syndrome; Retrospective Studies |
顯示於: | 醫學系 |
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