https://scholars.lib.ntu.edu.tw/handle/123456789/530103
標題: | Acute lobar nephronia is associated with a high incidence of renal scarring in childhood urinary tract infections | 作者: | Cheng C.-H. Tsau Y.-K. Chang C.-J. Chang Y.-C. Kuo C.-Y. I-JUNG TSAI Hsu Y.-H. Lin T.-Y. |
關鍵字: | acute focal bacterial nephritis; acute pyelonephritis; DMSA renal scintigraphy | 公開日期: | 2010 | 出版社: | Lippincott Williams and Wilkins | 卷: | 29 | 期: | 7 | 起(迄)頁: | 624-628 | 來源出版物: | Pediatric Infectious Disease Journal | 摘要: | Background: Acute lobar nephronia (ALN) is a severe nonliquefactive inflammatory renal bacterial infection, and requires a longer duration of treatment. The aim of this prospective study was to investigate renal scarring after ALN and to examine the risk factors for renal scarring in children with ALN compared with those with acute pyelonephritis (APN). Methods: Patients with computed tomography-diagnosed ALN were enrolled and randomly allocated, with serial entry, to either a 2-or 3-week antibiotic treatment regimen. Age-and gender-matched APN patients served as comparators. Patients underwent dimercaptosuccinic acid scintigraphy at least 6 months later to assess renal scarring. Results: A total of 218 children (109 ALN, 109 APN) were enrolled. The incidence of renal scarring was similar between 2-and 3-week treatment groups and was higher in ALN patients than in APN patients (89.0% vs. 34.9%, P < 0.001). Renal scarring was prone to occur in children with higher inflammatory indices and longer duration of fever before and after treatment. Multiple regression analysis on independent variables showed that only ALN was significantly associated with a higher incidence of renal scarring. Conclusions: Our results showed a new finding that ALN is associated with a very high incidence of renal scarring, in comparison to APN, irrespective of the duration of antibiotic treatment. ? 2010 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954349214&doi=10.1097%2fINF.0b013e3181d8631a&partnerID=40&md5=5d46d9ff97ac2c087d36105ecf7795d3 https://scholars.lib.ntu.edu.tw/handle/123456789/530103 |
ISSN: | 0891-3668 | DOI: | 10.1097/INF.0b013e3181d8631a | SDG/關鍵字: | antibiotic agent; succimer tc 99m; acute lobar nephronia; acute pyelonephritis; age distribution; antibiotic therapy; article; child; childhood disease; clinical trial; computer assisted tomography; controlled clinical trial; controlled study; disease association; disease duration; female; fever; human; inflammation; kidney disease; kidney scar; major clinical study; male; preschool child; priority journal; prospective study; randomized controlled trial; risk assessment; scintigraphy; sex difference; urinary tract infection; bacterial infection; Cicatrix; complication; incidence; infant; kidney; pathology; pyelonephritis; risk factor; urinary tract infection; Bacterial Infections; Child; Child, Preschool; Cicatrix; Female; Humans; Incidence; Infant; Kidney; Male; Prospective Studies; Pyelonephritis; Risk Factors; Urinary Tract Infections |
顯示於: | 醫學系 |
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