https://scholars.lib.ntu.edu.tw/handle/123456789/530289
標題: | Placenta Growth Factor Elevation in the Cord Blood of Premature Neonates Predicts Poor Pulmonary Outcome | 作者: | PO-NIEN TSAO SHU-CHEN WEI Su Y.-N. CHIEN-NAN LEE HUNG-CHIEH CHOU Hsieh W.-S. FON-JOU HSIEH |
公開日期: | 2004 | 卷: | 113 | 期: | 5 I | 起(迄)頁: | 1348-1351 | 來源出版物: | Pediatrics | 摘要: | Objective. To determine whether an elevated placenta growth factor (PlGF) level in cord blood is associated with increased risk for preterm infants to develop bronchopulmonary dysplasia (BPD). Methods. Sixty-three preterm infants who were born at 34 weeks' gestation or earlier were enrolled. Two infants who died before 28 days' postnatal age could not be assigned a BPD status and were excluded. PlGF levels in cord blood were measured using enzyme-linked immunosorbent assay. Mann-Whitney rank sum test, Spearman correlation coefficients, and multivariable linear or logistic regression analyses were used for statistical analysis. Results. The BPD group had a higher PlGF level, lower gestational age, lower birth weight (BW), higher incidence of endotracheal tube intubation, and longer duration of intubation. The PlGF levels in cord blood correlated negatively with gestational age and BW. However, multivariable logistic regression analyses revealed that only elevated cord blood PlGF levels and BW were associated with BPD after adjusting for all contributing factors. Furthermore, an increased PlGF level in cord blood was significantly correlated with the clinical severity of BPD, as measured by duration of intubation. At 17 mg/dL, the specificity of cord blood P1GF level in predicting BPD was 95%, the sensitivity was 53%, the positive predictive value was 83%, and the negative predictive value was 82%. Conclusions. Measuring cord blood PlGF level at birth might be a biological marker for predicting the occurrence of BPD and allowing early therapeutic intervention. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-2342505206&doi=10.1542%2fpeds.113.5.1348&partnerID=40&md5=be9702a1003aff64b8610f5821ee8dc8 https://scholars.lib.ntu.edu.tw/handle/123456789/530289 |
ISSN: | 0031-4005 | DOI: | 10.1542/peds.113.5.1348 | SDG/關鍵字: | biological marker; growth factor; placental growth factor; unclassified drug; article; correlation coefficient; disease severity; endotracheal intubation; enzyme linked immunosorbent assay; female; gestational age; human; logistic regression analysis; low birth weight; lung dysplasia; major clinical study; male; newborn; prediction; prematurity; priority journal; rank sum test; treatment outcome; umbilical cord blood; Biological Markers; Birth Weight; Bronchopulmonary Dysplasia; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; Predictive Value of Tests; Pregnancy Proteins; Risk Factors |
顯示於: | 醫學系 |
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