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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/530289
DC FieldValueLanguage
dc.contributor.authorPO-NIEN TSAOen_US
dc.contributor.authorSHU-CHEN WEIen_US
dc.contributor.authorSu Y.-N.en_US
dc.contributor.authorCHIEN-NAN LEEen_US
dc.contributor.authorHUNG-CHIEH CHOUen_US
dc.contributor.authorHsieh W.-S.en_US
dc.contributor.authorHsieh F.-J.en_US
dc.creatorPo-Nien Tsao;Wei S.-C.;Su Y.-N.;Lee C.-N.;Chou H.-C.;Hsieh W.-S.;Hsieh F.-J.-
dc.date.accessioned2020-12-22T03:29:48Z-
dc.date.available2020-12-22T03:29:48Z-
dc.date.issued2004-
dc.identifier.issn0031-4005-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-2342505206&doi=10.1542%2fpeds.113.5.1348&partnerID=40&md5=be9702a1003aff64b8610f5821ee8dc8-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/530289-
dc.description.abstractObjective. To determine whether an elevated placenta growth factor (PlGF) level in cord blood is associated with increased risk for preterm infants to develop bronchopulmonary dysplasia (BPD). Methods. Sixty-three preterm infants who were born at 34 weeks' gestation or earlier were enrolled. Two infants who died before 28 days' postnatal age could not be assigned a BPD status and were excluded. PlGF levels in cord blood were measured using enzyme-linked immunosorbent assay. Mann-Whitney rank sum test, Spearman correlation coefficients, and multivariable linear or logistic regression analyses were used for statistical analysis. Results. The BPD group had a higher PlGF level, lower gestational age, lower birth weight (BW), higher incidence of endotracheal tube intubation, and longer duration of intubation. The PlGF levels in cord blood correlated negatively with gestational age and BW. However, multivariable logistic regression analyses revealed that only elevated cord blood PlGF levels and BW were associated with BPD after adjusting for all contributing factors. Furthermore, an increased PlGF level in cord blood was significantly correlated with the clinical severity of BPD, as measured by duration of intubation. At 17 mg/dL, the specificity of cord blood P1GF level in predicting BPD was 95%, the sensitivity was 53%, the positive predictive value was 83%, and the negative predictive value was 82%. Conclusions. Measuring cord blood PlGF level at birth might be a biological marker for predicting the occurrence of BPD and allowing early therapeutic intervention.-
dc.relation.ispartofPediatrics-
dc.subject.otherbiological marker; growth factor; placental growth factor; unclassified drug; article; correlation coefficient; disease severity; endotracheal intubation; enzyme linked immunosorbent assay; female; gestational age; human; logistic regression analysis; low birth weight; lung dysplasia; major clinical study; male; newborn; prediction; prematurity; priority journal; rank sum test; treatment outcome; umbilical cord blood; Biological Markers; Birth Weight; Bronchopulmonary Dysplasia; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Male; Predictive Value of Tests; Pregnancy Proteins; Risk Factors-
dc.subject.other[SDGs]SDG3-
dc.titlePlacenta Growth Factor Elevation in the Cord Blood of Premature Neonates Predicts Poor Pulmonary Outcomeen_US
dc.typejournal article-
dc.identifier.doi10.1542/peds.113.5.1348-
dc.identifier.pmid15121952-
dc.identifier.scopus2-s2.0-2342505206-
dc.relation.pages1348-1351-
dc.relation.journalvolume113-
dc.relation.journalissue5 I-
item.fulltextno fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypejournal article-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
crisitem.author.deptPediatrics-
crisitem.author.deptPediatrics-NTUH-
crisitem.author.deptInternal Medicine-
crisitem.author.deptInternal Medicine-NTUH-
crisitem.author.deptObstetrics & Gynecology-
crisitem.author.deptMedical Genetics-NTUH-
crisitem.author.deptObstetrics & Gynecology-NTUH-
crisitem.author.deptPediatrics-
crisitem.author.deptPediatrics-NTUH-
crisitem.author.orcid0000-0002-6114-1769-
crisitem.author.orcid0000-0002-5017-5840-
crisitem.author.orcid0000-0002-1725-0407-
crisitem.author.orcid0000-0002-8932-9472-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgNational Taiwan University Hospital-
Appears in Collections:醫學系
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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