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  4. Impact of overweight and obesity on acute exacerbations of COPD - Subgroup analysis of the Taiwan obstructive llung disease cohort
 
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Impact of overweight and obesity on acute exacerbations of COPD - Subgroup analysis of the Taiwan obstructive llung disease cohort

Journal
International Journal of COPD
Journal Volume
12
Pages
2723-2729
Date Issued
2017
Author(s)
Wei Y.-F.
Tsai Y.-H.
Wang C.-C.
PING-HUNG KUO  
On behalf of the TOLD Study Group
DOI
10.2147/COPD.S138571
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029436614&doi=10.2147%2fCOPD.S138571&partnerID=40&md5=c2352bbe93ed1ba30404c846640aedb7
https://scholars.lib.ntu.edu.tw/handle/123456789/530831
Abstract
Purpose: A low body mass index (BMI) is a poor prognostic marker of acute exacerbations and mortality in patients with COPD. However, the impact of overweight and obesity on COPD-related outcomes is uncertain. The aim of this study was to examine whether a high BMI is associated with the frequent exacerbator phenotype (?2/year) in Taiwanese patients with COPD. Patients and methods: Data were obtained from the Taiwan Obstructive Lung Disease study, a retrospective, observational nationwide survey of COPD patients conducted at 12 hospitals in Taiwan. Multivariate logistic regression models were used to explore the association between BMI and other factors with the frequency of COPD exacerbations in these patients. Results: Among the whole study cohort (n=1,096), 735 (67.1%) had no exacerbations and 148 (13.5%) were frequent exacerbators in the previous year. The BMI values of the patients with 0, 1, and ?2 exacerbations were 23.6, 23.5, and 22.6 kg/m2, respectively. In all, 256 (23.4%) and 196 (17.9%) patients were overweight (27 kg/m2 > BMI ?24 kg/m2) and obese (BMI ?27 kg/m2), respectively. Even after adjusting for multiple factors, overweight and obesity were associated with the frequency of exacerbations (odds ratio [95% confidence interval] 0.49 [0.28-0.87, P=0.015] and 0.49 [0.26-0.94, P=0.033], respectively). Conclusion: Our results suggest that overweight and obesity are associated with a lower frequency of COPD exacerbations in Taiwan. ? 2017 Wei et al.
SDGs

[SDGs]SDG3

Other Subjects
adipocytokine; adiponectin; antibiotic agent; leptin; steroid; adult; age; anxiety; Article; body mass; cardiovascular disease; chronic obstructive lung disease; clinical study; cohort analysis; congestive heart failure; depression; diabetes mellitus; disease exacerbation; dyslipidemia; female; gender; health care survey; heart arrhythmia; human; hypertension; ischemic heart disease; lung cancer; lung function; major clinical study; male; malignant neoplasm; obesity; observational study; osteoporosis; retrospective study; smoking; Taiwan; wheezing; chronic obstructive lung disease; clinical trial; comorbidity; disease exacerbation; lung; multicenter study; multivariate analysis; obesity; odds ratio; pathophysiology; phenotype; protection; risk factor; statistical model; Body Mass Index; Comorbidity; Disease Progression; Female; Humans; Logistic Models; Lung; Male; Multivariate Analysis; Obesity; Odds Ratio; Overweight; Phenotype; Protective Factors; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Risk Factors; Taiwan
Publisher
Dove Medical Press Ltd.
Type
journal article

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