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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/530831
Title: Impact of overweight and obesity on acute exacerbations of COPD - Subgroup analysis of the Taiwan obstructive llung disease cohort
Authors: Wei Y.-F.
Tsai Y.-H.
Wang C.-C.
PING-HUNG KUO 
On behalf of the TOLD Study Group
Issue Date: 2017
Publisher: Dove Medical Press Ltd.
Journal Volume: 12
Start page/Pages: 2723-2729
Source: International Journal of COPD
Abstract: 
Purpose: A low body mass index (BMI) is a poor prognostic marker of acute exacerbations and mortality in patients with COPD. However, the impact of overweight and obesity on COPD-related outcomes is uncertain. The aim of this study was to examine whether a high BMI is associated with the frequent exacerbator phenotype (?2/year) in Taiwanese patients with COPD. Patients and methods: Data were obtained from the Taiwan Obstructive Lung Disease study, a retrospective, observational nationwide survey of COPD patients conducted at 12 hospitals in Taiwan. Multivariate logistic regression models were used to explore the association between BMI and other factors with the frequency of COPD exacerbations in these patients. Results: Among the whole study cohort (n=1,096), 735 (67.1%) had no exacerbations and 148 (13.5%) were frequent exacerbators in the previous year. The BMI values of the patients with 0, 1, and ?2 exacerbations were 23.6, 23.5, and 22.6 kg/m2, respectively. In all, 256 (23.4%) and 196 (17.9%) patients were overweight (27 kg/m2 > BMI ?24 kg/m2) and obese (BMI ?27 kg/m2), respectively. Even after adjusting for multiple factors, overweight and obesity were associated with the frequency of exacerbations (odds ratio [95% confidence interval] 0.49 [0.28-0.87, P=0.015] and 0.49 [0.26-0.94, P=0.033], respectively). Conclusion: Our results suggest that overweight and obesity are associated with a lower frequency of COPD exacerbations in Taiwan. ? 2017 Wei et al.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029436614&doi=10.2147%2fCOPD.S138571&partnerID=40&md5=c2352bbe93ed1ba30404c846640aedb7
https://scholars.lib.ntu.edu.tw/handle/123456789/530831
ISSN: 1176-9106
DOI: 10.2147/COPD.S138571
SDG/Keyword: adipocytokine; adiponectin; antibiotic agent; leptin; steroid; adult; age; anxiety; Article; body mass; cardiovascular disease; chronic obstructive lung disease; clinical study; cohort analysis; congestive heart failure; depression; diabetes mellitus; disease exacerbation; dyslipidemia; female; gender; health care survey; heart arrhythmia; human; hypertension; ischemic heart disease; lung cancer; lung function; major clinical study; male; malignant neoplasm; obesity; observational study; osteoporosis; retrospective study; smoking; Taiwan; wheezing; chronic obstructive lung disease; clinical trial; comorbidity; disease exacerbation; lung; multicenter study; multivariate analysis; obesity; odds ratio; pathophysiology; phenotype; protection; risk factor; statistical model; Body Mass Index; Comorbidity; Disease Progression; Female; Humans; Logistic Models; Lung; Male; Multivariate Analysis; Obesity; Odds Ratio; Overweight; Phenotype; Protective Factors; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Risk Factors; Taiwan
[SDGs]SDG3
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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