|Title:||Factors associated with the prescription of inhaled corticosteroids in GOLD group A and B patients with COPD – Subgroup analysis of the Taiwan obstructive lung disease cohort||Authors:||Wei Y.-F.
|Issue Date:||2015||Publisher:||Dove Medical Press Ltd.||Journal Volume:||10||Journal Issue:||1||Start page/Pages:||1951-1956||Source:||International Journal of COPD||Abstract:||
Background and objective: The overprescription of inhaled corticosteroids (ICS) in the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) group A and B patients with chronic obstructive pulmonary disease (COPD) is not uncommon in clinical practice. The aim of this study was to explore the factors associated with the use of ICS in these patients. Methods: The Taiwan obstructive lung disease (TOLD) study was a retrospective, observational nationwide survey of COPD patients conducted at 12 hospitals (n=1,096) in Taiwan. Multivariate logistic regression models were used to explore the predictors of ICS prescription in GOLD group A and B patients. Results: Among the group A (n=179) and group B (n=398) patients, 198 (34.3%) were prescribed ICS (30.2% in group A and 36.2% in group B, respectively). The wheezing phenotype was present in 28.5% of group A and 34.2% of group B patients. Wheezing was the most significant factor for an ICS prescription in group A (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.14-4.75; P=0.020), group B (OR, 1.93; 95% CI, 1.24-2.99; P=0.004), and overall (OR, 2.04; 95% CI, 1.40-2.96; P<0.001). The COPD assessment test score was also associated with an ICS prescription in group B (OR, 1.04; 95% CI, 1.00-1.07; P=0.038). Conclusion: About one-third of the GOLD group A and B patients with COPD in Taiwan are prescribed ICS. Our findings suggest that wheezing and COPD assessment test score are related to the prescription of ICS in these patients. ? 2015 Wei et al.
|ISSN:||1176-9106||DOI:||10.2147/COPD.S88114||SDG/Keyword:||corticosteroid; bronchodilating agent; corticosteroid; adult; Article; chronic obstructive lung disease; COPD assessment test; drug utilization; female; human; major clinical study; male; observational study; prescription; respiratory tract disease assessment; retrospective study; risk factor; Taiwan; wheezing; abnormal respiratory sound; aged; classification; inhalational drug administration; middle aged; multivariate analysis; odds ratio; pathophysiology; Pulmonary Disease, Chronic Obstructive; severity of illness index; statistical model; very elderly; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Bronchodilator Agents; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pulmonary Disease, Chronic Obstructive; Respiratory Sounds; Retrospective Studies; Severity of Illness Index; Taiwan
|Appears in Collections:||醫學系|
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