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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/530837
Title: Factors associated with the prescription of inhaled corticosteroids in GOLD group A and B patients with COPD – Subgroup analysis of the Taiwan obstructive lung disease cohort
Authors: Wei Y.-F.
PING-HUNG KUO 
Tsai Y.-H.
Tao C.-W.
Cheng S.-L.
Lee C.-H.
Wu Y.-K.
Chen N.-H.
Hsu W.-H.
Hsu J.-Y.
Lin M.-S.
Wang C.-C.
Issue Date: 2015
Publisher: Dove Medical Press Ltd.
Journal Volume: 10
Journal Issue: 1
Start page/Pages: 1951-1956
Source: International Journal of COPD
Abstract: 
Background and objective: The overprescription of inhaled corticosteroids (ICS) in the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) group A and B patients with chronic obstructive pulmonary disease (COPD) is not uncommon in clinical practice. The aim of this study was to explore the factors associated with the use of ICS in these patients. Methods: The Taiwan obstructive lung disease (TOLD) study was a retrospective, observational nationwide survey of COPD patients conducted at 12 hospitals (n=1,096) in Taiwan. Multivariate logistic regression models were used to explore the predictors of ICS prescription in GOLD group A and B patients. Results: Among the group A (n=179) and group B (n=398) patients, 198 (34.3%) were prescribed ICS (30.2% in group A and 36.2% in group B, respectively). The wheezing phenotype was present in 28.5% of group A and 34.2% of group B patients. Wheezing was the most significant factor for an ICS prescription in group A (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.14-4.75; P=0.020), group B (OR, 1.93; 95% CI, 1.24-2.99; P=0.004), and overall (OR, 2.04; 95% CI, 1.40-2.96; P<0.001). The COPD assessment test score was also associated with an ICS prescription in group B (OR, 1.04; 95% CI, 1.00-1.07; P=0.038). Conclusion: About one-third of the GOLD group A and B patients with COPD in Taiwan are prescribed ICS. Our findings suggest that wheezing and COPD assessment test score are related to the prescription of ICS in these patients. ? 2015 Wei et al.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941889823&doi=10.2147%2fCOPD.S88114&partnerID=40&md5=c01b345a56e6502d94ad102046b778a3
https://scholars.lib.ntu.edu.tw/handle/123456789/530837
ISSN: 1176-9106
DOI: 10.2147/COPD.S88114
SDG/Keyword: corticosteroid; bronchodilating agent; corticosteroid; adult; Article; chronic obstructive lung disease; COPD assessment test; drug utilization; female; human; major clinical study; male; observational study; prescription; respiratory tract disease assessment; retrospective study; risk factor; Taiwan; wheezing; abnormal respiratory sound; aged; classification; inhalational drug administration; middle aged; multivariate analysis; odds ratio; pathophysiology; Pulmonary Disease, Chronic Obstructive; severity of illness index; statistical model; very elderly; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Bronchodilator Agents; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pulmonary Disease, Chronic Obstructive; Respiratory Sounds; Retrospective Studies; Severity of Illness Index; Taiwan
[SDGs]SDG3
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