https://scholars.lib.ntu.edu.tw/handle/123456789/531719
標題: | Advanced Age and Chronic Kidney Disease Modify the Association between Metabolic Syndrome and Frailty among Community-Dwelling Elderly | 作者: | CHIA-TER CHAO YI-HSUAN LEE Li C.-M. DER-SHENG HAN JENQ-WEN HUANG Huang K.-C. |
公開日期: | 2020 | 出版社: | Mary Ann Liebert Inc. | 卷: | 23 | 期: | 4 | 起(迄)頁: | 333-340 | 來源出版物: | Rejuvenation Research | 摘要: | Metabolic syndrome (MetS) predisposes older adults to the development of frailty. However, previous studies have not explored factors that may influence the association between MetS and the risk of frailty in this population. Community-dwelling older adults (?65 years of age) were prospectively identified and enrolled between 2013 and 2016. MetS and frailty were defined based on the American Association of Clinical Endocrinologists and Study of Osteoporotic Fractures criteria, respectively. Multiple logistic regression with frailty/prefrailty as the dependent variable was used to examine the relationship between MetS and frailty/prefrailty, supplemented by subgroup analyses of the influence of aging and chronic kidney disease (CKD). Among 2862 elderly (73.4 ± 6.7 years), 17.5% and 17.3%, respectively, had MetS and frailty/prefrailty, among whom 74 (2.6%) and 420 (14.7%) had frailty and prefrailty. The presence of MetS (odds ratio [OR] 2.53, p < 0.001), higher age (OR 1.05, p < 0.001), and CKD (OR 1.42, p = 0.006) were associated with a significantly higher risk of frailty/prefrailty. Furthermore, among those ?80 years of age, the association between MetS and frailty/prefrailty disappeared (p = 0.329). Among those with CKD, the presence of MetS was significantly associated with a progressively higher risk of frailty/prefrailty (for stage 3 or higher and for stage 3b or higher, OR 6.4 and 12.4, p < 0.001 and = 0.009, respectively). In conclusion, aging and CKD modified the association between MetS and frailty. These findings may assist in devising case-specific care plans for elderly with MetS by refocusing our attention on those at high risk of developing frailty/prefrailty. ? Copyright 2020, Mary Ann Liebert, Inc., publishers. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078557624&doi=10.1089%2frej.2019.2202&partnerID=40&md5=41d44f61e7bac63bfba2b01161eca269 https://scholars.lib.ntu.edu.tw/handle/123456789/531719 |
ISSN: | 1549-1684 | DOI: | 10.1089/rej.2019.2202 | SDG/關鍵字: | creatinine; aged; aging; anamnesis; Article; chronic kidney failure; community dwelling person; comorbidity assessment; controlled study; creatinine blood level; dependent variable; female; fragility fracture; frailty; geriatrics; human; laboratory test; major clinical study; male; medical examination; metabolic syndrome X; multivariate logistic regression analysis; physical examination; priority journal; chronic kidney failure; complication; frailty; geriatric assessment; independent living; metabolic syndrome X; pathology; pathophysiology; Aged; Aging; Female; Frailty; Geriatric Assessment; Humans; Independent Living; Male; Metabolic Syndrome; Renal Insufficiency, Chronic |
顯示於: | 醫學系 |
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