https://scholars.lib.ntu.edu.tw/handle/123456789/531720
標題: | Gustatory function and the uremic toxin, phosphate, are modulators of the risk of vascular calcification among patients with chronic kidney disease: A pilot study | 作者: | Chen S.-I. Chiang C.-L. CHIA-TER CHAO CHIH-KANG CHIANG JENQ-WEN HUANG |
公開日期: | 2020 | 出版社: | MDPI AG | 卷: | 12 | 期: | 6 | 起(迄)頁: | 420 | 來源出版物: | Toxins | 摘要: | Patients with chronic kidney disease (CKD) have an increased risk of vascular calcification (VC), including aortic arch calcification (AAC). Few investigated the influence of gustatory function on the probability of having VC. We examined whether gustatory function results modulated the probability of having VC in patients with CKD. We prospectively enrolled adults with CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2), with their AAC rated semi-quantitatively and gustatory function assessed by objective and subjective approaches. Multiple logistic regression was used to analyze the relationship between gustatory function results and AAC. Those with AAC had significantly better objective gustatory function in aggregate scores (p = 0.039) and categories (p = 0.022) and less defective bitter taste (p = 0.045) and scores (p = 0.037) than those without. Multiple regression analyses showed that higher aggregate scores (odds ratio (OR) 1.288, p = 0.032), or better gustatory function, and higher bitter taste scores (OR 2.558, p = 0.019) were each associated with a higher probability of having AAC among CKD patients; such an association was modulated by serum phosphate levels. In conclusion, better gustatory function was independently correlated with having AAC among CKD patients. A follow-up of VC severity may be an underrecognized component of care for CKD patients with a preserved gustatory function. ? 2020 by the authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087739945&doi=10.3390%2ftoxins12060420&partnerID=40&md5=ccf3af519fc567966b1b35e3655e484d https://scholars.lib.ntu.edu.tw/handle/123456789/531720 |
ISSN: | 2072-6651 | DOI: | 10.3390/toxins12060420 | SDG/關鍵字: | phosphate; uremic toxin; biological marker; phosphate; aged; Article; blood vessel calcification; body mass; chronic kidney failure; chronic obstructive lung disease; end stage renal disease; estimated glomerular filtration rate; female; food frequency questionnaire; food intake; glomerulus filtration rate; grip strength; human; hypertension; inflammatory bowel disease; major clinical study; male; malnutrition; nutritional status; phosphate blood level; pilot study; prospective study; risk assessment; scoring system; sweat gland disease; visual analog scale; waist circumference; blood; blood vessel calcification; chronic kidney failure; comparative study; complication; cross-sectional study; middle aged; pathophysiology; risk factor; taste; taste disorder; uremia; very elderly; Aged; Aged, 80 and over; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Phosphates; Pilot Projects; Prospective Studies; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Taste; Taste Disorders; Uremia; Vascular Calcification |
顯示於: | 醫學系 |
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