https://scholars.lib.ntu.edu.tw/handle/123456789/531772
標題: | Vitamin D is closely linked to the clinical courses of herpes zoster: From pathogenesis to complications | 作者: | CHIA-TER CHAO CHIH-KANG CHIANG JENQ-WEN HUANG KUAN-YU HUNG |
公開日期: | 2015 | 出版社: | Churchill Livingstone | 卷: | 85 | 期: | 4 | 起(迄)頁: | 452-457 | 來源出版物: | Medical Hypotheses | 摘要: | Vitamin D is renowned for its pleiotropic effects, including but not limited to bone integrity, and it has assumed an important role in the current research era. As vitamin D receptors are present in a variety of human tissues, particularly immune cells, the immunomodulatory potential of vitamin D cannot be overemphasized. Herpes zoster, which presents as grouped cutaneous vesicles over dermatomes or visceral/central nervous system infection in its severe form, has a higher incidence in immune-suppressed patients. Considering the importance of vitamin D in host immunity, we hypothesize that vitamin D acts as an effect-modifier for the entire herpes zoster spectrum with regard to disease susceptibility, manifestation, efficacy of pharmacologic management, and emergent complications during treatment. Moreover, the possibility exists that vitamin D might affect the course of postherpetic neuralgia. In line with this theory, we comprehensively searched the existing herpes zoster literature and provided important insight into the relationship between the disease courses of herpes zoster and vitamin D. ? 2015 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942500596&doi=10.1016%2fj.mehy.2015.06.027&partnerID=40&md5=968297be22b2a834ac6c39e544119886 https://scholars.lib.ntu.edu.tw/handle/123456789/531772 |
ISSN: | 0306-9877 | DOI: | 10.1016/j.mehy.2015.06.027 | SDG/關鍵字: | 1,25 dihydroxyergocalciferol; 5 (2 bromovinyl) 2' deoxyuridine; aciclovir; beta defensin 2; cathelicidin antimicrobial peptide LL 37; famciclovir; nitric oxide synthase; retinoid X receptor; toll like receptor 1; toll like receptor 2; valaciclovir; vitamin D; vitamin D receptor; vitamin D; adaptive immunity; Article; clinical feature; disease association; disease course; disease predisposition; drug efficacy; drug futility; genetic susceptibility; herpes zoster; high risk population; human; immunomodulation; incidence; infection risk; innate immunity; nonhuman; nutritional status; pathogenesis; pharmacological parameters; postherpetic neuralgia; systemic therapy; Th1 cell; Th2 cell; virus reactivation; virus replication; virus survival; vitamin blood level; vitamin D deficiency; bone; complication; herpes zoster; immune system; immunology; immunosuppressive treatment; metabolism; pathophysiology; physiology; postherpetic neuralgia; skin; theoretical model; virology; Adaptive Immunity; Bone and Bones; Herpes Zoster; Humans; Immune System; Immunity, Innate; Immunosuppression; Models, Theoretical; Neuralgia, Postherpetic; Skin; Vitamin D |
顯示於: | 醫學系 |
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