https://scholars.lib.ntu.edu.tw/handle/123456789/531858
標題: | Peritoneal fibrosing syndrome: Pathogenetic mechanism and current therapeutic strategies | 作者: | KUAN-YU HUNG JENQ-WEN HUANG TUN-JUN TSAI Hsieh B.-S. |
公開日期: | 2005 | 出版社: | Chinese Medical Association - Taipei | 卷: | 68 | 期: | 9 | 起(迄)頁: | 401-405 | 來源出版物: | Journal of the Chinese Medical Association | 摘要: | Peritoneal dialysis (PD) has been established as a main renal replacement therapy for approximately 20 years. However, long-term peritoneal exposure to high glucose and other unphysiologic contents in the PD solution may potentiate the development of peritoneal fibrosing syndrome (PFS) in PD patients. PFS is composed of a wide spectrum of peritoneal alterations, which has been observed in PD patients. Molecular studies have shown that the fibrogenic effect of peritoneal mesothelial cells and the accompanying accumulation of extracellular matrix in the peritoneum are key events leading to PFS. In this review, we highlight the impact of PFS and its pathogenetic factors, including bioincompatible PD solution, multidisciplinary inflammatory mediators, and stimulatory cytokines in the peritoneal cavity. Current therapeutic strategies based on both clinical and basic evidence for the prevention or treatment of PFS are also reviewed. ? 2005 Elsevier. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-25444484710&doi=10.1016%2fS1726-4901%2809%2970154-6&partnerID=40&md5=453a44056b7a5b0a4d24fb5563443547 https://scholars.lib.ntu.edu.tw/handle/123456789/531858 |
ISSN: | 1726-4901 | DOI: | 10.1016/S1726-4901(09)70154-6 | SDG/關鍵字: | cytokine; dialysis fluid; dipyridamole; glucocorticoid; glucose; pentoxifylline; tamoxifen; biocompatibility; drug mechanism; extracellular matrix; fibrogenesis; gene therapy; human; in vitro study; in vivo study; inflammation; long term care; mesothelium cell; molecular mechanics; nonhuman; pathogenesis; patient care; peritoneal cavity; peritoneal dialysis; peritoneal disease; peritoneal fibrosing syndrome; protein localization; review; risk factor; tissue distribution |
顯示於: | 醫學系 |
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